Results 141 to 150 of about 15,113,067 (348)

Comrades or Foes: Did the Russians Break the Law or New Ground for the First Amendment? [PDF]

open access: yes, 2019
This Article discusses the recent decision by the United States Federal Government to indict more than a dozen Russian nationals for conspiracy to defraud the United States of America. The Government accused the Russians of staging protests, distributing
Caspar, Samantha M., Joukov, Artem M.
core   +1 more source

Trastuzumab, paclitaxel, carboplatin, and gemcitabine in advanced human epidermal growth factor receptor-2/neu-positive urothelial carcinoma: results of a multicenter phase II National Cancer Institute trial.

open access: yesJournal of Clinical Oncology, 2007
M. Hussain   +11 more
semanticscholar   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

China in D. Trump’s Free and Open Indo-Pacific Strategy

open access: yesVestnik RUDN. International Relations, 2019
With Trump as a president of the US from January 2017 and his decisive actions, which have undermined many agreements reached by previous American administrations (like withdrawal from the TTP, the Paris climate agreement, the Iran nuclear deal, the UNESCO, etc.), the international system and regional subsystems are under serious reconfiguration and ...
openaire   +3 more sources

X-linked retinoschisis: an update

open access: yesJournal of Medical Genetics, 2006
S. Sikkink   +4 more
semanticscholar   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Donald Trump’s Second Presidency: National Interest vs. ‘Rules-Based Order’?

open access: yesВестник Московского Университета. Серия XXV: Международные отношения и мировая политика
From the outset of his second presidential term, Donald Trump proclaimed a fundamental reassessment of Washington’s foreign policy priorities, explicitlyasserting the primacy of the U.S. national interests over the globalist objectives of maintaining the
P. Ye. Smirnov
doaj   +1 more source

An overview of Notch3 function in vascular smooth muscle cells.

open access: yesProgress in Biophysics and Molecular Biology, 2008
Tao Wang, M. Baron, D. Trump
semanticscholar   +1 more source

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