Results 51 to 60 of about 1,351 (149)
Let a ‘heuristic’ be any preference or behavior that is anticipated to facilitate the achievement of some long-term objective, to wit, an objective which comprises of, at the very least, two sequential sub-objectives. The choice of any specific heuristic
Oghenovo Adewale Obrimah
doaj +1 more source
Cryo‐EM reveals ArnA contamination during purification of a ciliary protein complex
ArnA contamination was independently observed during the purification of a soluble, low‐yield protein complex, leading to an unintended 3.23 Å resolution cryo‐EM structure. This work broadens recent findings and highlights ArnA as a recurrent His‐tag‐associated contaminant in Escherichia coli purification workflows.Endogenous Escherichia coli proteins ...
Xuguang Jiang, Masahide Kikkawa
wiley +1 more source
Universally, it remains unknown which clauses used in international sales contracts are seen by the business sector as crucial for reducing perceived risks.
Hinčica Vít +2 more
doaj +1 more source
Outranking Methods: Promethee I and Promethee II
This article highlights the application of the Preference Ranking Organization Method for Enrichment of Evaluations (PROMETHEE) I and II in selecting the best laptop model among six different available models in the market. Seven important criteria, that
Goswami Shankha Shubhra
doaj +1 more source
Simple incentives and diverse beliefs
This paper studies a moral hazard problem in which the principal does not know the agent's beliefs about the output generating process. The agent is risk neutral, transfers are subject to limited liability, and the principal evaluates contracts according to their worst‐case payoff against a rich set of plausible agent beliefs.
Maxwell Rosenthal
wiley +1 more source
This study investigates the nonlinear impact of foreign economic policy uncertainty (EPU) on foreign direct investment (FDI) inflows across 21 Asia-Pacific economies from 1993 to 2023.
Tran Thi Mai Thanh, To Ngoc Lan
doaj +1 more source
Sustainability Balanced Scorecard Architecture and Environmental Investment Decision-Making
This study is centered around a set of research questions that aim to explain how sustainability balanced scorecard architectures with sustainability parameters either embedded or treated as a separate perspective relate to environmental investment ...
Jassem Suaad +2 more
doaj +1 more source
Conformational Trajectory of the Molecular Chameleon Grazoprevir From Formulation to Target‐Bound
ABSTRACT Macrocycles represent a promising class of beyond‐rule‐of‐5 (bRo5) therapeutics, capable of targeting proteins traditionally considered undruggable by conventional small molecules. Macrocycles exhibit intrinsic flexibility and often display a “chameleon‐like” ability to adapt to their environment, thereby enhancing their oral bioavailability ...
Lianne H. E. Wieske +5 more
wiley +1 more source
Using small‐angle neutron scattering (SANS) with deuterated lipid substitution and contrast variation, this work examines the core–shell structure of KC2 lipid nanoparticles, their water content and exchange properties, structural changes during heating and acidification, and compositional distribution and phase complexity via invariant analysis. These
Haikun Liu +12 more
wiley +1 more source
SURFS and AlphaFold Reveal Ribosome Footprint Shift Caused by EF-Tu D81 Mutation
Summary Protein synthesis relies on accurate mRNA decoding by tRNA, a process guided by EF-Tu. We investigated how mutations at a conserved residue, aspartate 81, affect EF-Tu function using GTPase assays, AlphaFold modeling, and quantum-sensing-based super-resolution force spectroscopy (SURFS). All D81 variants retained GTPase activity
Yi Zeng +3 more
openaire +2 more sources

