Results 61 to 70 of about 1,148,539 (314)

The Near-infrared Transmission Spectra of TRAPPIST-1 Planets b, c, d, e, f, and g and Stellar Contamination in Multi-epoch Transit Spectra [PDF]

The Astronomical Journal, 2018
Abstract The seven approximately Earth-sized transiting planets in the TRAPPIST-1 system provide a unique opportunity to explore habitable- and nonhabitable-zone small planets within the same system. Its habitable-zone exoplanets—due to their favorable transit depths—are also worlds for which atmospheric transmission spectroscopy is ...
Zhanbo Zhang, Yifan Zhou, Benjamin V. Rackham, Dániel Apai   +3 more
openaire   +3 more sources

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Planning electricity transmission to accommodate renewables: Using two-stage programming to evaluate flexibility and the cost of disregarding uncertainty

, 2012
We develop a stochastic two-stage optimisation model that captures the multistage nature of electricity transmission planning under uncertainty and apply it to a stylised representation of the Great Britain (GB) network.

core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Age patterns of severe paediatric malaria and their relationship to Plasmodium falciparum transmission intensity. [PDF]

, 2009
BACKGROUND: The understanding of the epidemiology of severe malaria in African children remains incomplete across the spectrum of Plasmodium falciparum transmission intensities through which communities might expect to transition, as intervention ...
Abdullah Al-Taiar, Idro, Richard, Okiro Emelda A, Berkley, James, Al-Taiar Abdullah, Berkley James A, Berkley, James A, Snow, Robert, Al-Taiar, Abdullah, Berkley, JA, Emelda A Okiro, Okiro, EA, James A Berkley, Snow, Robert W, Okiro, Emelda A, Idro, R, Snow, RW, Robert W Snow, Snow Robert W, Reyburn, H, Hugh Reyburn, Richard Idro, Reyburn Hugh, Al-Taiar, A, Reyburn, Hugh, Idro Richard   +25 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Evaluation of Extended Storage of Swine Complete Feed for Inactivation of Viral Contamination and Effect on Nutritional, Microbiological, and Toxicological Profiles

Animals
The extended storage of feed ingredients has been suggested as a method to mitigate the risk of pathogen transmission through contaminated ingredients.
Jordan T. Gebhardt, Scott A. Dee, Erin Little, Brittney N. Scales, Doug R. Kern   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Heterosynaptic long-term potentiation from the anterior cingulate cortex to spinal cord in adult rats

Molecular Pain, 2018
Spinal nociceptive transmission receives biphasic modulation from supraspinal structures. Recent studies demonstrate that the anterior cingulate cortex facilitates spinal excitatory synaptic transmission and nociceptive reflex.
Qi-Yu Chen, Tao Chen, Li-Jun Zhou, Xian-Guo Liu, Min Zhuo   +4 more
doaj   +1 more source

Investigation of Performance Evaluation and Design Techniques for Large Industrial Mufflers [PDF]

, 2013
This document is the culmination of an investigation into the techniques used to design and evaluate the acoustic performance of large industrial mufflers using three-dimensional acoustic theory. Three performance criteria were considered.
Mang, Scott
core