Results 61 to 70 of about 34,593,801 (261)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 1911 148 p., [12] leaves of plates : ill., col. maps ; 30 cm.2nd edition of History, plan and scope of the American Museum of Natural History, 1910 (https://digitallibrary.amnh.org/handle/2246 ...
Osborn, Henry Fairfield, 1857-1935 +3 more
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Merino: history, culture and landscape [PDF]
, 2023 Book chapter, Merinos in South Africa, published in MERINO: history, culture and landscape, by Prames PublishersThe history and background of Merino farming in South Africa, and the development of the breed are addressed.
Bath, Gareth
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Human Vaccines & Immunotherapeutics, 2017 This phase III, non-randomized, open-label, multi-center study (NCT01827839) evaluated the immunogenicity and safety of an adjuvanted recombinant subunit herpes zoster (HZ) vaccine (HZ/su) in adults aged ≥ 50 y with prior physician-documented history of ...
Olivier Godeaux +7 more
doaj +1 more source
The unphysical character of minimally coupled dark energy fluids
European Physical Journal C: Particles and Fields, 2019 It is well known that, in the context of general relativity, an unknown kind of matter that must violate the strong energy condition is required to explain the current accelerated phase of expansion of the Universe.
Ronaldo C. Duarte +3 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source