Results 101 to 110 of about 21,696,412 (297)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Valuing the Historic Environment: a critical review of existing approaches to social value [PDF]
, 2015 Through a critical review of existing research, this report examines current knowledge and understanding of social value. Encompassing the significance of the historic environment to contemporary communities, social value relates to people’s sense ...
Jones, Sian +3 more
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
R&D, Agency Costs and Capital Structure: International Evidence [PDF]
We examine the impact of R&D intensity and agency costs on the value of firms across 13 economies. We find that R&D adds value while high agency costs reduce value. R&D adds value, however, even when agency costs are high.
Sinclair Davidson, Robert Brooks
core
PharmacyBackground: Limitations in timely and equitable access to essential medicines among older adults not only constitute a clinical barrier to the effective management of chronic conditions, but also represent a violation of the fundamental right to life ...
Doris Cardona +6 more
doaj +1 more source
VITAMIN D VALUE IN DIAGNOSIS AND TREATMENT OF HYPERPARATHYROIDISM
Alʹmanah Kliničeskoj Mediciny, 2016 Background: Pathophysiologic interaction between vitamin D and hyperparathyroidism (HPT) is under investigation, never being systematically studied and remaining incompletely understood till now.
S. N. Pamputis +2 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
An elevated D-dimer value: a burden on our patients and hospitals
, 2012 Nitin Chopra, Pradeep Doddamreddy, Hermanjeet Grewal, Pratap C KumarJackson Park Hospital, Chicago, IL, USAAbstract: With 200,000 annual deaths in the United States due to pulmonary embolism (PE), efficient and accurate diagnosis is mandatory.
Chopra N +3 more
core
REPRESENTATION OF VALUE AND SALIENCE IN THE PRIMATE BRAIN [PDF]
, 2015 Most times, we choose goods and avoid evils. Sometimes, goods and evils choose us, which quickly grabs our attention. How do our brains represent our values so that we can choose? How do things we love or loathe automatically capture our attention?
LEATHERS, MARVIN L, LEATHERS, MARVIN/L
core
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source