Results 111 to 120 of about 21,696,412 (297)

Definitions and meanings of value

, 2017
This chapter gives an introduction to The Value of Events and sets the stage for subsequent contributions by providing an overview of the most fundamental concepts.
Tommy D. Andersson, Donald Getz, Andersson, Tommy D.,, Erik Lundberg, John Armbrecht, Getz, Donald,, Armbrecht, John,, Lundberg, Erik,   +7 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Perspectives of clinical stakeholders and patients from four VA liver clinics to tailor practice facilitation for implementing evidence-based alcohol-related care

Addiction Science & Clinical Practice
Background Unhealthy alcohol use (UAU) is particularly dangerous for people with chronic liver disease. Liver clinics may be an important setting in which to provide effective alcohol-related care by integrating evidence-based strategies, such as brief ...
Elena M. Soyer, Madeline C. Frost, Olivia V. Fletcher, George N. Ioannou, Judith I. Tsui, E. Jennifer Edelman, Bryan J. Weiner, Rachel L. Bachrach, Jessica A. Chen, Emily C. Williams   +9 more
doaj   +1 more source

On Causal Inferences for Personalized Medicine: How Hidden Causal Assumptions Led to Erroneous Causal Claims About the D-Value. [PDF]

Am Stat, 2020
Greenland S, Fay MP, Brittain EH, Shih JH, Follmann DA, Gabriel EE, Robins JM.   +6 more
europepmc   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The Value of Failures in Pharmaceutical R&D [PDF]

We build a cumulative innovation model in which both success and failure provide valuable information for future research. To test this learning mechanism, we use a dataset covering outcomes of world-wide R&D projects in the pharmaceutical industry, and ...
Fabio Pammolli, Massimo Riccaboni, Jing-Yuan Chio, Laura Magazzini   +3 more
core  

MEDIATION OF CHEMOTHERAPY-INDUCED APOPTOSIS BY THE LYSOSOMAL PROTEASE CATHEPSIN D [PDF]

, 2005
One of the most common hallmarks of cancer is dysregulation of cellular apoptotic processes. A comprehensive knowledge of the underlying mechanisms of the apoptotic machinery is vital for the identification of new drug targets and the development of ...
Emert-Sedlak, Lori A
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Investment, R&D and liquidity constraints [PDF]

In this contribution, we present a novel instrument to control for investment opportunities in studying the investment-cash-flow sensitivity. More in particular we introduce the book value of R&D.
Pr. D. Patrick Van Cayseele
core  

Patient-Reported Health-Related Quality of Life Impact and Symptom Severity in Patients with Lyme Borreliosis in the Burden of Lyme Disease (BOLD) Study

Pathogens
Lyme borreliosis (LB) can manifest as a localized infection or, if left untreated, disseminated disease. This analysis used Patient-Reported Outcome tools to assess general health, fatigue, pain, and cognitive function in patients with localized or ...
Holly Yu, Amanda R. Mercadante, Kate Halsby, Alexandra Loew-Baselli, Ye Tan, Juanita Edwards, Frederick J. Angulo, Elizabeth Begier, Mendwas Dzingina, Johan S. Berglund, Anna Moniuszko-Malinowska, Franc Strle, James H. Stark, on behalf of the BOLD Study Group   +13 more
doaj   +1 more source