Results 131 to 140 of about 21,696,412 (297)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Approach to create transparency on the efficiency of R&D processes by applying Value Stream Mapping

, 2014
considered as generating, evaluating and developing ideas in order to create new products, processes or services in a short period of time. Comparing innovation processes with e.g.
Sihn, Wilfried, Steinwender, Arko, Gommel, Henrik, Schieder, Peter   +3 more
core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Enzymatic interesterification of freshwater fish oil from grass carp (Ctenopharyngodon idella) viscera: a novel approach to mitigate fishy odors through lipid restructuring

Food Chemistry: X
This study explores enzymatic interesterification of grass carp visceral fish oil and coconut oil, examining its impacts on lipidomic and flavoromic profiles via UHPLC-Q-TOF/MS and GC–MS.
Jinlin Li, Huijuan Zhou, Linchuan Xu, Chengwei Yu, Mingming Hu, Bizhen Zhong, Zongcai Tu, Bin Peng   +7 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Integrated lipidomics and flavoromics approach elucidates the antioxidant-mediated preservation mechanisms in silver carp (Hypophthalmichthys molitrix) visceral fish oil during thermal processing

Food Chemistry: X
Integrated lipidomics and flavoromics were employed to elucidate the mechanism of antioxidants in mitigating flavor deterioration of fish oil from silver carp viscera.
Bin Peng, Linchuan Xu, Liping Yuan, Chengwei Yu, Mingming Hu, Bizheng Zhong, Zongcai Tu, Jinlin Li   +7 more
doaj   +1 more source

Interval-Valued Neutrosophic N-d-ideal in d-algebra

Neutrosophic Optimization and Intelligent Systems
In this article we present the concept of interval-valued neutrosophic N-d-ideal by applying interval-valued neutrosophic N-structure to d-ideal of algebraic structure d-algebra. We proved that an interval-valued neutrosophic N-d-ideal's pre-image and image under homeomorphism and epimorphism, respectively, are also interval-valued neutrosophic N-d ...
Bavanari Satyanarayana, Shake Baji
openaire   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Tubular proteinuria and vitamin D deficiency in sickle cell disease [PDF]

, 2019
Kidney disease is a significant complication of sickle cell disease (SCD) with great public health concern, causing over 18% of total patient mortality. Proximal tubule (PT) dysfunction, including tubular proteinuria, is a common early symptom of kidney ...
Gliozzi, Megan
core  

The influence of disease severity and lifestyle factors on the peak annual 25(OH)D value of COPD patients. [PDF]

Int J Chron Obstruct Pulmon Dis, 2018
Kentson M, Leanderson P, Jacobson P, Persson HL.   +3 more
europepmc   +1 more source