Results 141 to 150 of about 23,467,166 (293)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Tubular proteinuria and vitamin D deficiency in sickle cell disease [PDF]
, 2019 Kidney disease is a significant complication of sickle cell disease (SCD) with great public health concern, causing over 18% of total patient mortality. Proximal tubule (PT) dysfunction, including tubular proteinuria, is a common early symptom of kidney ...
Gliozzi, Megan
core
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Impact of R&D Spillovers on Export Value: Does the Transmission Channel matter? [PDF]
There is overwhelming evidence in the literature that open economies benefit from spillover effects from foreign R&D efforts. These effects increase in particular total factor productivity.
Jan Van Hove
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2020 ABSTRAKHubungan Nomophobia dengan Keterampilan Sosial pada Mahasiswa Prodi D IvKeperawatan Magelang Poltekkes Kemenkes SemarangKharisma Nurul Hapsari1, Hermani Triredjeki2, Tulus Puji Hastuti2Email : kharismahapsari99@gmail.com, 1)Mahasiswa Program ...
Kharisma Nurul Hapsari
core
Improving Construction Processes by Integrating Lean, Green, and Six-Sigma [PDF]
, 2013 The overall goal of this research was to develop and implement methods to improve the performance and the efficiency of construction processes prior to and during the construction phase in Design-Bid-Build (DBB) projects.
Banawi, Abdulaziz
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source