Results 111 to 120 of about 8,156 (311)

B4GALNT4‐Mediated Glycosylation of PDK1 Activates the PI3K‐AKT Signaling Pathway to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
This study identifies B4GALNT4 as a key driver of prostate cancer (PCa). It shows that B4GALNT4 glycosylates PDK1 protein at the N531 site, which stabilizes the PDK1 and constitutively activates the PI3K‐AKT pathway. This mechanism promotes tumor cell proliferation, migration, and invasion. The findings establish the B4GALNT4‐PDK1 glycosylation axis as
Shaoqin Jiang, Mengqiang Li, Qingfu Su, Ruiling Dou, Shaoshan Lin, Jili Zhang, Xiaochen Sun, Haolan Yu, Wei Bao, Min Qu, Yan Wang, Chenghua Yang, Xu Gao   +12 more
wiley   +1 more source

Analysis of the influence of switching related parameters in the dab converter under soft-switching [PDF]

, 2013
An analysis of a dual active bridge (DAB) converter under soft-switching mode in the whole operating range is presented in this paper. A detailed study of the impact ofthe transformer magnetizing inductance, LM,and snubber capacitance, Cxx, parameters on
García, Guillermo, Oggier, German Gustavo, Oliva, Alejandro Raul   +2 more
core  

Impedance interaction modeling and analysis for bidirectional cascaded converters [PDF]

, 2015
© 2015 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new ...
Chen, Zhe, Deng, Fujin, Hu, Yanting, Sun, Xiaofeng, Tian, Yanjun   +4 more
core   +1 more source

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

An optimal control for dual active bridge converter in battery charging applications

IET Power Electronics
Dual active bridge (DAB) converter is an ideal bidirectional DC/DC converter and serves as a core device for enabling bidirectional energy transfer in power router systems and energy storage units.
Junrui Wang, Xuanjing Qiao, Linhui Li, Ruiqi Li   +3 more
doaj   +1 more source

A Virtual Inertia-Based Power Feedforward Control Strategy for an Energy Router in a Direct Current Microgrid Application

Energies, 2019
Due to the uncertainty of the power load and the randomness of distributed generations, low-voltage direct current (LVDC) bus voltage fluctuation will greatly affect the safety of an energy router-enabled direct current (DC) microgrid.
Yuyang Li, Qiuye Sun, Danlu Wang, Sen Lin   +3 more
doaj   +1 more source

Asymmetric matching DC/DC converter for electric power system with battery energy storage system [PDF]

, 2018
В статье описывается новая топология и алгоритм управления ключами обратимого двухзвенного преобразователя постоянного напряжения с трансформаторной развязкой.
Блинов, Андрей Борисович, Замаруев, Владимир Васильевич, Ивахно, Владимир Викторович, Стысло, Богдан Александрович   +3 more
core   +1 more source

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Sensorless Open-Circuit-Fault Diagnosis Method for NPC-Based DAB Converter [PDF]

IEEE Transactions on Power Electronics
Open-circuit fault (OCF) on power switches can cause a severe threat to operation and safety of power electronic converters. In the neutral-point-clamped (NPC)-based dual-active-bridge (DAB) converters, the OCFs will result in an increase in the current stress, DC bias, and capacitor voltage imbalance.
Chaochao Song, Ariya Sangwongwanich, Frede Blaabjerg   +2 more
openaire   +1 more source