Results 61 to 70 of about 542 (103)

A nomogram and heat map based on LASSO‐Cox regression for predicting the risk of early‐stage severe fever with thrombocytopenia syndrome patients developing into critical illness at 7‐day and 14‐day

Journal of Medical Virology, Volume 96, Issue 9, September 2024.
Abstract Severe fever with thrombocytopenia syndrome (SFTS) represents an emerging infectious disease characterized by a substantial mortality risk. Early identification of patients is crucial for effective risk assessment and timely interventions. In the present study, least absolute shrinkage and selection operator (LASSO)‐Cox regression analysis was
Hanwen Tong, Jun Wang, Naisheng Zhu, Haopeng Li, Yu Zhai, Binxia Shao, Huiying Li, Peng Xia, Yunfei Jiang, Chenxiao Jiang, Yun Liu   +10 more
wiley   +1 more source

Clinical and etiological characteristics of severe hemorrhagic fever caused by coinfection of hantaan orthohantavirus and severe fever with thrombocytopenia syndrome virus

Journal of Medical Virology, Volume 96, Issue 9, September 2024.
Abstract Severe fever with thrombocytopenia syndrome (SFTS) and hemorrhagic fever with renal syndrome (HFRS) usually have different infection routes, and coinfection is relatively rare. This study examines the clinical and etiological characteristics of coinfection by these two pathogens to provide important references for clinical diagnosis and ...
Feng Jiang, Yongxiang Zhao, Ruihao Peng, Ya Wen, Yudan Bi, Yichen Zhou, Yao Chen, Hua Deng, Xiaohu Han, Zeliang Chen   +9 more
wiley   +1 more source

Phenology and habitat associations of the invasive Asian longhorned tick from Ohio, USA

Medical and Veterinary Entomology, Volume 38, Issue 3, Page 314-324, September 2024.
Asian longhorned tick (ALT) nymphs emerged in June, followed by adults, and concluded with larvae in fall. Potential differences in phenology were identified between Ohio and Eastern Coast US states. ALTs were detected in all habitat types including grassland, forest and edge, but not on wildlife hosts, including small‐ and medium‐sized mammals and ...
Andreas Eleftheriou, Benjamin Zeiger, Jazmin Jennings, Risa Pesapane   +3 more
wiley   +1 more source

Activation of neurotoxic A1‐reactive astrocytes by SFTS virus infection accelerates fatal brain damage in IFNAR1‐/‐ mice

Journal of Medical Virology, Volume 96, Issue 8, August 2024.
Abstract Severe fever with thrombocytopenia syndrome (SFTS) has a high mortality rate compared to other infectious diseases. SFTS is particularly associated with a high risk of mortality in immunocompromised individuals, while most patients who die of SFTS exhibit symptoms of severe encephalitis before death.
Seon‐Hee Kim, Ha Nyeoung Choi, Min Gi Jo, Bina Lee, Young Jin Kim, Hyemin Seong, Chieun Song, Han Sol Yoo, Jeong Hyun Lee, Daseul Seong, Hyun‐Jin Park, In‐Soon Roh, Jinsung Yang, Min Young Lee, Hye Jung Kim, Sang Won Park, Mingyo Kim, Seong Jae Kim, Minkyeong Kim, Hyun‐Jeong Kim, Kyung‐Wook Hong, Seung Pil Yun   +21 more
wiley   +1 more source

Characterisation of putative novel tick viruses and zoonotic risk prediction

Ecology and Evolution, Volume 14, Issue 1, January 2024.
Tick‐borne viruses remain a substantial zoonotic risk worldwide, so knowledge of the diversity of tick viruses has potential health consequences. Through data mining and bioinformatic analyses of more than 37,800 public meta‐genomic and ‐transcriptomic data sets, we found five putative novel Alphatetra‐like viruses, four putative novel Orthomyxo‐like ...
Yuting Lin, David J. Pascall
wiley   +1 more source

Co-Circulation of Tick-Borne Bandaviruses and Orthonairoviruses Across Humans, Livestock, and Rats in Pakistan: Serologic Evidence and Public Health Implications

Viruses
Tick-borne viruses (TBVs) pose significant public health and economic threats. Pakistan has endemic Crimean-Congo hemorrhagic fever virus (CCHFV), but evidence suggests broader TBV circulation.
Muhammad Ammar, Shengyao Chen, Muhammad Saqib, Jingyuan Zhang, Awais-Ur-Rahman Sial, Asad Zia, Yaohui Fang, Muhammad Khalid Mansoor, Abulimiti Moming, Asim Shahzad, Rehman Hafeez, Aneela Javed, Ali Hassan, Ben Hu, Ali Zohaib, Shu Shen, Fei Deng   +16 more
doaj   +1 more source

SNX11-Deletion Inhibit Dabie Bandavirus Infection by Interfering with the Synthesis of V-ATPase

SNX11, a sorting nexin protein localized on the endosomal membrane, is an important protein closely related to protein sorting and endosomal trafficking. Previously, through a genome-wide CRISPR screening, we identified SNX11 as a critical protein for the entry of Dabie bandavirus.
Tiezhu Liu, Xueqi Wang, Yang Fang, Ping Zhang, Qiang Sun, Jiandong Li, Shiwen Wang   +6 more
openaire   +1 more source

Downregulation of transcription 1 hinders the replication of Dabie bandavirus by promoting the expression of TLR7, TLR8, and TLR9 signaling pathway

Ticks and Tick-borne Diseases
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a bunyavirus that causes SFTS, with a case fatality rate of up to 30 %. The innate immune system plays a crucial role in the defense against SFTSV; however, the impact of viral propagation of STFSV on the innate immune system remains unclear.
Hao An, Xiaoli Yu, Yumei Liu, Lei Fang, Ming Shu, Qingfeng Zhai, Junhao Chen   +6 more
openaire   +3 more sources

Bioinformatics Design of a DBV-Specific Multi-Epitope Vaccine [PDF]

BIO Web of Conferences
Objective This study aims to design and optimize a multi-epitope vaccine against Dabie bandavirus (DBV) using bioinformatics approaches, and to systematically evaluate its structural stability, antigenicity, and immunogenicity, thereby providing a ...
Zhu Yuheng, Liu Jingxian, Xiao Zhongdang
doaj   +1 more source

Development and validation of a nomogram for predicting 30-day mortality in DBV-induced sepsis with pancreatic injury

iScience
Summary: Dabie Bandavirus (DBV)-induced sepsis is a life-threatening disease in which pancreatic injury (PI) is common, yet its severity determinants and prognostic significance remain unclear.
Meng Zhang, Wei Liu, Yuxin Niu, Yunhui Liu, Lanyue Huang, Yuzhao Feng, Chuanwen Chen, Lifen Hu, Tao Chen, Qin Ning   +9 more
doaj   +1 more source