Results 121 to 130 of about 48,696 (305)

The clinical effectiveness and cost-effectiveness of point-of-care tests (CoaguChek system, INRatio2 PT/INR monitor and ProTime Microcoagulation system) for the self-monitoring of the coagulation status of people receiving long-term vitamin K antagonist therapy, compared with standard UK practice : systematic review and economic evaluation [PDF]

, 2015
Funding The National Institute for Health Research Health Technology Assessment programme.Peer reviewedPublisher ...
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Clinical associations and prognosis in Asian and European patients with symptom‐controlled atrial fibrillation: Insights from two prospective registries in Europe and Asia

European Journal of Clinical Investigation, Volume 55, Issue 11, November 2025.
Symptom‐controlled atrial fibrillation (AF), defined as asymptomatic or with mild symptoms according to the European Heart Rhythm Association (EHRA) score, was more common among Asians than in Europeans. In Asians, comorbidities of diabetes, hypertension, and prior ischemic stroke increase the likelihood of being scAF.
Wee Siong Teo, Manlin Zhao, Tommaso Bucci, Steven Ho Man Lam, Hongyu Liu, Yang Chen, Giuseppe Boriani, Hung‐Fat Tse, Tze‐Fan Chao, Gregory Y. H. Lip   +9 more
wiley   +1 more source

Evidence of comparative efficacy should have a formal role in European drug approvals [PDF]

, 2011
Despite methodological concerns, comparative efficacy evidence should be required at the time of drug approval, says Corinna Sorenson and colleagues, to allow patients, clinicians, and other healthcare decision makers to determine whether a new drug is ...
Cylus, Jonathan, Mossialos, Elias, Naci, Huseyin, Sorenson, Corinna   +3 more
core   +1 more source

Oral anticoagulation in patients with gastrointestinal bleeding and new‐onset atrial fibrillation: A population‐based registry‐linkage study

Journal of Internal Medicine, Volume 298, Issue 5, Page 450-463, November 2025.
Abstract Background Limited data exist on the prevalence of gastrointestinal bleeding (GIB) in patients with new‐onset atrial fibrillation (AF) and the impact of GIB on the initiation of oral anticoagulation (OAC) therapy. Methods A population‐based registry‐linkage study included all patients diagnosed with new‐onset AF in Finland during 2010–2018 who
Santeri Jolkkonen, Jukka Putaala, Konsta Teppo, Pirjo Mustonen, Jussi Jaakkola, Aapo Aro, Olli Halminen, Ossi Lehtonen, Jari Haukka, Miika Linna, Juha Hartikainen, K. E. Juhani Airaksinen, Mika Lehto   +12 more
wiley   +1 more source

Dabigatran etexilate for secondary stroke prevention: the first year experience from a multicenter short-term registry

Therapeutic Advances in Neurological Disorders, 2014
Background: There are growing concerns for the side effects of dabigatran etexilate (dabigatran), including higher incidence of dyspepsia and gastrointestinal bleeding.
Georgios Tsivgoulis, Christos Krogias, Kara A. Sands, Vijay K. Sharma, Aristeidis H. Katsanos, Konstantinos Vadikolias, Sokratis G. Papageorgiou, Ioannis Heliopoulos, Harn Shiue, Athina Mitsoglou, Chrissoula Liantinioti, Dimitrios Athanasiadis, Sotirios Giannopoulos, Charitomeni Piperidou, Konstantinos Voumvourakis, Andrei V. Alexandrov   +15 more
doaj   +1 more source

Cost-effectiveness of dabigatran versus genotype-guided management of warfarin therapy for stroke prevention in patients with atrial fibrillation.

PLoS ONE, 2012
BackgroundDabigatran is associated with lower rate of stroke comparing to warfarin when anticoagulation control is sub-optimal. Genotype-guided warfarin dosing and management may improve patient-time in target range (TTR) and therefore affect the cost ...
Joyce H S You, Kia K N Tsui, Raymond S M Wong, Gergory Cheng   +3 more
doaj   +1 more source

Managing atrial fibrillation in the global community: The European perspective. [PDF]

, 2013
Atrial fibrillation is a common, global problem, with great personal, economic and social burdens. As populations age it increases in prevalence and becomes another condition that requires careful chronic management to ensure its effects are minimised ...
Camm, AJ, Kaba, RA, Sharma, R, Williams, TM   +3 more
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Prorenin in Hepatic Stellate Cell Extracellular Vesicles Induces Platelet‐Dependent Thrombin Formation and Release of Profibrotic TGF‐β

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
Platelets interact with extracellular vesicles shed by hepatic stellate cells to activate both cell types. Extracellular vesicles shed by activated hepatic stellate cells contain inactive prorenin. HSC‐EV interact with quiescent platelets to non‐proteolytically activate ligated prorenin.
Rui Chen, Emily Huang, Xianfang Wu, Megan R. McMullen, Xianjia Wang, Laura E. Nagy, Ge Jin, Scott J. Cameron, Thomas M. McIntyre   +8 more
wiley   +1 more source

Dabigatran experience in primary and secondary prevention of cardioembolic stroke

Неврология, нейропсихиатрия, психосоматика, 2013
The review of novel oral anticoagulants (dabigatran, rivaroxaban and apixaban) in stroke prevention and also own data of administration of dabigatran in primary and secondary prevention of ischemic stroke in 45 patients with cerebrovascular diseases are ...
Maksim Alekseyevich Domashenko, M Yu Maksimova, D Z Korobkova, M E Gafarova   +3 more
doaj   +1 more source

Prior-preconditioned conjugate gradient method for accelerated Gibbs sampling in "large $n$ & large $p$" sparse Bayesian regression

, 2020
In a modern observational study based on healthcare databases, the number of observations and of predictors typically range in the order of $10^5$ ~ $10^6$ and of $10^4$ ~ $10^5$.
Nishimura, Akihiko, Suchard, Marc A.
core   +1 more source