Results 121 to 130 of about 49,135 (301)

Concerns Regarding the Use of Dabigatran for Stroke Prevention in Atrial Fibrillation

Pharmaceuticals, 2012
Dabigatran is an oral thrombin inhibitor which has been approved in several countries as an alternative to vitamin-K-antagonists for the prevention of stroke or embolism in atrial fibrillation patients.
Josef Finsterer, Claudia Stöllberger
doaj   +1 more source

Oral anticoagulants for primary prevention, treatment and secondary prevention of venous thromboembolic disease, and for prevention of stroke in atrial fibrillation:systematic review, network meta-analysis and cost-effectiveness analysis [PDF]

, 2017
BACKGROUND: Warfarin is effective for stroke prevention in atrial fibrillation (AF), but anticoagulation is underused in clinical care. The risk of venous thromboembolic disease during hospitalisation can be reduced by low-molecular-weight heparin (LMWH):
Sterne, Jonathan Ac, Bodalia, Pritesh N, Bryden, Peter A, Davies, Philippa A, López-López, Jose A, Okoli, George N, Thom, Howard Hz, Caldwell, Deborah M, Dias, Sofia, Eaton, Diane, Higgins, Julian Pt, Hollingworth, William, Salisbury, Chris, Savović, Jelena, Sofat, Reecha, Stephens-Boal, Annya, Welton, Nicky J, Hingorani, Aroon D   +17 more
core   +3 more sources

Dabigatran and apolipoprotein B [PDF]

Heart, 2015
Dabigatran is the first of a series of new direct acting oral anticoagulants that was clinically introduced for the prevention of ischaemic stroke in patients with atrial fibrillation (AF). In the randomized evaluation of long-term anticoagulation therapy (RE-LY) study, dabigatran was shown to be superior or non-inferior to warfarin in preventing ...
openaire   +2 more sources

High‐Throughput Screening Using the Self‐Controlled Tree‐Based Scan Statistic to Identify Medications Associated With Hospitalization for Severe Acute Liver Injury

Pharmacoepidemiology and Drug Safety, Volume 34, Issue 12, December 2025.
ABSTRACT Background Medications associated with acute liver injury (ALI) are primarily identified by case reports. High‐throughput screening of real‐world data could be leveraged to detect hepatotoxicity signals. Objective To apply tree‐based scan statistics in real‐world data to identify drugs associated with hospitalization for severe ALI among ...
Vincent Lo Re III, Craig W. Newcomb, Dean M. Carbonari, Charles E. Leonard, Christopher T. Rentsch, Judith C. Maro   +5 more
wiley   +1 more source

Safety and Efficacy of Minimally Interrupted Dabigatran vs Uninterrupted Warfarin Therapy in Adults Undergoing Atrial Fibrillation Catheter Ablation: A Randomized Clinical Trial.

JAMA Network Open, 2019
Importance Uninterrupted dabigatran therapy reduces stroke risk in patients with nonvalvular atrial fibrillation (NVAF) undergoing ablation and is associated with a lower bleeding risk than uninterrupted warfarin therapy.
A. Nogami, T. Harada, Y. Sekiguchi, R. Otani, Y. Yoshida, Kentaro Yoshida, Yukiko Nakano, N. Nuruki, Shiro Nakahara, M. Goya, H. Origasa, Y. Kihara, K. Hirao, K. Aonuma   +13 more
semanticscholar   +1 more source

Impact of Direct Oral Anticoagulant Uptake on Hospitalizations for Stroke/Transient Ischemic Attack, Intracranial Hemorrhage, and Gastrointestinal Bleeding in Individuals With Atrial Fibrillation: A Population‐Based Study

Fundamental &Clinical Pharmacology, Volume 39, Issue 6, December 2025.
ABSTRACT Background Direct‐acting oral anticoagulants (DOACs) have largely replaced warfarin for stroke prevention in patients with atrial fibrillation, yet their population‐level impact on health outcomes and costs remains unclear. We examined whether the widespread uptake of DOACs was associated with changes in hospitalization rates and costs for ...
Tony Antoniou, Daniel McCormack, Tianru Wang, Mina Tadrous, Tara Gomes   +4 more
wiley   +1 more source

Teendők súlyos vérzés vagy sürgős sebészeti beavatkozás esetén direkt orális antikoaguláns gyógyszerrel kezeltekben. Az új dabigatran-antidótum: idarucizumab helye a klinikai gyakorlatban [PDF]

, 2016
Absztrakt Az elmúlt hat évtizedben csak a K-vitamin-antagonista kumarinokat alkalmazhattuk orális antikoagulánsként.
Boda, Zoltán
core   +1 more source

Dabigatran-induced esophagitis

Cleveland Clinic Journal of Medicine, 2019
The tablets contain tartaric acid, and if they get stuck in the esophagus, the acid leaching out can damage the mucosa.
openaire   +2 more sources

Delphi Consensus Among French Obesity Experts on Clinical Recommendations for Drug Prescription in Patients With Severe Obesity

Obesity Reviews, Volume 26, Issue 12, December 2025.
ABSTRACT Introduction Although the physiologic alterations seen in obesity often affect the pharmacokinetics and pharmacodynamics of drugs, most clinical trials do not consider these aspects specifically for this population. To date, there is no list of potentially inappropriate medications for patients living with obesity. The aim of this study was to
Sarah Berdot, Germain Perrin, Emmanuel Disse, Armelle Arnoux, Eric Bertin, Anne‐Laure Borel, Marie‐Claude Brindisi, Arnaud De Luca, Edouard‐Jules Laforgue, Jean‐Daniel Lalau, Yann Matussiere, Emilie Montastier, Agnès Sallé, Bérénice Segrestin, Valentine Suteau, French Hospital Expert Panel, Sebastien Czernichow, Brigitte Sabatier   +17 more
wiley   +1 more source

Factors affecting serum concentration of dabigatran in Asian patients with non-valvular atrial fibrillation

Journal of the Formosan Medical Association, 2019
Background/purpose: Dabigatran is effective in preventing ischemic stroke and systemic embolism in patients with atrial fibrillation. Although the therapeutic window for dabigatran is wide, its pharmacokinetic properties can differ between specific ...
Shin-Yi Lin, Sung-Chun Tang, Ching-Hua Kuo, Li-Kai Tsai, Shin-Joe Yeh, Li-Jiuan Shen, Jiann-Shing Jeng   +6 more
doaj   +1 more source