Results 51 to 60 of about 38,476 (212)

Population Pharmacokinetics Analysis of Talazoparib and Enzalutamide Combination Therapy for Patients With Metastatic Castration‐Resistant Prostate Cancer

The Journal of Clinical Pharmacology, EarlyView.
Abstract The poly(ADP‐ribose) polymerase inhibitor talazoparib, combined with the androgen receptor inhibitor enzalutamide is approved for patients with homologous recombination repair (HRR) gene‐mutated metastatic castration‐resistant prostate cancer (mCRPC) in the US and with mCRPC in whom chemotherapy is not clinically indicated in Europe.
Mark Hadigol, Jason H. Williams, Haihong Shi, Derek Z. Yang, Justin Hoffman, Diane D. Wang   +5 more
wiley   +1 more source

Possible Interaction between Dabigatran and Ranolazine in Patients with Renal Failure

Medicina, 2019
Dabigatran etexilate is a direct oral anticoagulant (thrombin inhibitor) used for the prevention of stroke and systemic thromboembolic events in patients with permanent atrial fibrillation; prevention of venous thromboembolic events and deep veins ...
Gintautas Gumbrevičius, Gytė Damulevičienė, Vaidotas Galaunė, Milda Gumbrevičiūtė   +3 more
doaj   +1 more source

New oral anticoagulants and their reversal agents [PDF]

, 2018
Atrial fibrillation is a commonly encountered pathology in medical practice, and its prevalence has shown a continuous rise over the past years. Atrial fibrillation has a significant impact on patients\u27 quality of life, not only due to the standard ...
Bodean, Oana, Diaconu, Camelia C, Laslo, Crista L, Marcu, Dragos, Neagu, Tiberiu P, Paduraru, Dan N, Pantea Stoian, Anca, Socea, Bogdan, Socea, Laura I, Stanescu, Ana Maria Alexandra   +9 more
core   +1 more source

Effect of Testosterone Therapy on Cytochrome P450 3A and P‐Glycoprotein Activities Using Midazolam and Digoxin as Probe Substrates Among Transgender Adults

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
ABSTRACT Background Gender‐affirming testosterone therapy is one part of the standard of care for more than 1 million transgender adults in the United States. Testosterone therapy may influence the activities of drug‐metabolizing enzymes and transporters, but knowledge about its effect on the pharmacokinetics of other medications is limited.
Michiko Hunter, Rene Coig, Linda Risler, Kristen K. Patton, Radhika R. Narla, Dina N. Greene, Alson K. Burke, Elizabeth Micks, Mary F. Hebert, Lauren R. Cirrincione   +9 more
wiley   +1 more source

Coagulopathy and Extremely Elevated PT/INR after Dabigatran Etexilate Use in a Patient with End-Stage Renal Disease

Case Reports in Medicine, 2013
Introduction. Dabigatran is an oral direct thrombin inhibitor which has been approved for prophylaxis of stroke in patients with atrial fibrillation. The use of dabigatran etexilate increased rapidly due to many benefits.
Joonseok Kim, Mrinal Yadava, In Chul An, Abrar Sayeed, Heather S. Laird-Fick, Venu Gourineni, George S. Abela   +6 more
doaj   +1 more source

Relative effects of different non-vitamin K antagonist oral anticoagulants on global thrombotic status in atrial fibrillation [PDF]

, 2016
This is an Accepted Manuscript of an article published by Taylor & Francis GroupNon-vitamin K antagonist oral anticoagulants (NOACs) reduce the risk of thromboembolism in patients with atrial fibrillation (AF).
Artman, Benjamin, Farag, Mohamed, Gorog, Diana A, Khan, Arif, Niespialowska-Steuden, Maria, Okafor, Osita, Srinivasan, Manivannan, Sullivan, Keith, Wellsted, David   +8 more
core   +2 more sources

Measuring Direct Oral Anticoagulant (DOAC) Levels: Applications, Limitations, and Future Directions

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction There are important challenges with the measurement and interpretation of direct oral anticoagulant (DOAC) anticoagulant effect including a lack of therapeutic ranges, inaccuracy of routinely available coagulation assays, lack of established thresholds for clinically significant effect, and uncertainty about how to apply the ...
Siraj Mithoowani, Chee Wee Tan, Deborah M. Siegal   +2 more
wiley   +1 more source

Hemoclot Thrombin Inhibitor Assay and Expected Peak-Trough Levels of Dabigatran: A Multicenter Study

Frontiers in Cardiovascular Medicine, 2022
PurposeDabigatran concentrations monitoring are gaining importance of special situations, but limited data are available for the expected peak and trough levels. The hemoclot thrombin inhibitor (HTI) is dabigatran-calibrated quantitative determination of
Zhiyan Liu, Guangyan Mu, Qiufen Xie, Hanxu Zhang, Hanxu Zhang, Jie Jiang, Qian Xiang, Yimin Cui, Yimin Cui, Yimin Cui   +9 more
doaj   +1 more source

Post‐thrombotic syndrome in patients with venous thromboembolism treated with dabigatran or warfarin: A long‐term cross‐sectional follow‐up of RE‐COVER study patients [PDF]

, 2021
Hilde Skuterud Wik, Susan R. Kahn, Henry Eriksson, David Morrison, Waleed Ghanima, Sam Schulman, Per Morten Sandset   +6 more
openalex   +1 more source

Acute Efficacy of Pulsed‐Field Ablation of the Mitral Isthmus Using a Pentaspline Catheter and Two Different Ablation Settings

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Introduction There is limited data regarding the use of pulsed‐field ablation (PFA) for mitral isthmus (MI) ablation in patients with non‐paroxysmal atrial fibrillation (AF). Our aim was to assess the acute efficacy of MI ablation using a pentaspline PFA catheter with two different ablation settings.
Josef Hornof, Marek Hozman, Dalibor Heřman, Oleksii Romanenko, Sabri Hassouna, Jana Veselá, Věra Filipcová, Lukáš Povišer, Jakub Karch, Jana Hozmanová, Lucie Znojilová, Anna Molová, Vojtěch Pěnkava, Pavel Osmančík   +13 more
wiley   +1 more source