Results 41 to 50 of about 8,627 (176)

New safety standards for anticoagulant therapy in the treatment of atrial fibrillation

Российский кардиологический журнал, 2018
The review article study the safety and efficacy of using direct acting oral anticoagulants: thrombin inhibitor dabigatran etexilate and inhibitors Xa of the blood clotting factor apixaban, rivaroxaban and edoxaban compared with the vitamin K antagonist ...
E. I. Baranova
doaj   +1 more source

Assessment of the Drug-Drug Interaction Potential of Lotiglipron (PF-07081532) with Midazolam, Omeprazole, Dabigatran, Rosuvastatin, and the Oral Contraceptives Levonorgestrel and Ethinyl Estradiol. [PDF]

J Clin Pharmacol
Abstract Two Phase 1 open‐label studies were conducted in otherwise healthy participants, with BMI classified as overweight/obesity, to assess the potential of lotiglipron (a glucagon‐like peptide‐1 receptor agonist) as precipitant for pharmacokinetic (PK) drug–drug interactions (DDIs) when co‐administered with substrates of cytochrome P450 (CYP) 3A ...
Cronenberger C, Amin NB, Le VH, Carvajal-Gonzalez S, Ashworth AL, Yi EC, Schuster T, Zhang Y, Frederich RC, Friedman GS, Wang EQ, Tsamandouras N.   +11 more
europepmc   +2 more sources

Investigation of Solid-State Hydrate-Anhydrous Phase Transformations of Dabigatran Etexilate Hemi-Edisylate

Crystals, 2023
In this study, a dabigatran etexilate edisylate (DBE) was prepared by the reaction crystallization of dabigatran etexilate (DBG) and edisilic acid. According to single crystal X-ray diffraction (SXRD), it was revealed that two DGB were combined with one ...
Jin Feng, Changjin Lim, Sihyun Nam, Woojin Yoon, Hoseop Yun, Woo-Sik Kim, Ji-Hun An   +6 more
doaj   +1 more source

Dabigatran of etexilate (paradox®) for the patients with closed diaphyseal fractures of the femur and tibia

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2014
The results of application of dabigatran etexilate in treatment of 56 patients aged 60 to 89 with closed diaphyseal fractures of femur and tibia undergone intramedullary osteosynthesis were studied. The patients were divided into 2 groups.
A. K. Dulaev, A. N. Tsed, I. G. Dzhusoev
doaj   +1 more source

Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in UK patients with atrial fibrillation [PDF]

, 2011
Objective To assess the cost-effectiveness of dabigatran etexilate, a new oral anticoagulant, versus warfarin and other alternatives for the prevention of stroke and systemic embolism in UK patients with atrial fibrillation (AF).
Pan, Feng, Plumb, Jonathan M, Gani, Ray, Robinson, Paul, Kansal, Anuraag R, Sorensen, Sonja V, Cowie, Martin R   +6 more
core   +1 more source

The development and validation of analytical methods for the quantitative determination of dabigatran etexilate by HPLC-DAD and UV spectrophotometry during a comparative dissolution kinetics test of dabigatran capsules in the biorelevant FaSSGF medium

Разработка и регистрация лекарственных средств
Introduction. Venous thromboembolism and atrial fibrillation are significant causes of vascular mortality. Anticoagulant therapy significantly reduces the risk of ischemic stroke, and dabigatran etexilate, a direct thrombin inhibitor, has become firmly ...
D. M. Devyatkina, P. S. Mashchenko, A. D. Vnutskikh, I. O. Devyatkin, N. A. Prozorova, A. V. Foteeva   +5 more
doaj   +1 more source

DABIGATRAN ETEXILATE FOR PREVENTION OF CARDIOEMBOLIC COMPLICATIONS IN NONVALVULAR ATRIAL FIBRILLATION: HOW TO DO THE INTERVENTION MORE EFFECTIVE AND SAFER

Рациональная фармакотерапия в кардиологии, 2016
Application of dabigatran etexilate for prevention of cardioembolic complications in nonvalvular atrial fibrillation is considered. Results of randomized clinical trials on efficacy and safety of dabigatran in various doses are discussed.
I. S. Yavelov
doaj   +1 more source

Comparative differences in the risk of major gastrointestinal bleeding among different direct oral anticoagulants: An updated traditional and Bayesian network meta-analysis

Frontiers in Pharmacology, 2023
Background: The most favorable gastrointestinal (GI) bleeding safety profile among different types of direct oral anticoagulants (DOACs) remains controversial. This meta-analysis includes the latest studies and aims to compare GI bleeding risk associated
Xiuehui Chen, Lili Wang, Huijun Li, Weichao Huang, Lingyue Zhao, Wenqin Guo   +5 more
doaj   +1 more source

Current practice and guideline adherence in renal dose adjustment for patients with chronic kidney disease: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims To quantify prescribing adherence to renal dosing recommendations in adults with chronic kidney disease (CKD; Stage 3 and above) and to evaluate the clinical consequences of non‐adherence. Methods This systematic review and meta‐analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD42025620883).
Hager ElGeed, Ahmed Tehemar, Mohamed Gasimelseed, Ahmed Gharaibeh, Muhammad Abdul Hadi, Kazeem Yusuff, Amani Zidan, Ahmed Awaisu   +7 more
wiley   +1 more source

Practical use of dabigatran etexilate for stroke prevention in atrial fibrillation [PDF]

, 2013
Atrial fibrillation (AF) is associated with an increased risk of thromboembolism, and is the most prevalent factor for cardioembolic stroke. Vitamin K antagonists (VKAs) have been the standard of care for stroke prevention in patients with AF since the ...
Merkely, Béla Péter, Connolly SJ, Widimský, P, Christory F, Kiss, R G, Dan, G-A, Hatala, R, Vinereanu, D, Kher, A, Pieske, B, Kher A, Meier, B, Potpara, T, Huber K, Stępińska, J, Connolly, S J, Christory, F, Merkely, B, Huber, K, Klun, N Vene, Dan GA, Kiss, Róbert Gábor   +21 more
core   +2 more sources