Results 61 to 70 of about 14,647 (219)

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter‐Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™)

Clinical Pharmacology &Therapeutics, EarlyView.
Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe, Andrea Whitcher‐Johnstone, Aniruddha Karve, Diane Ramsden, Niresh Hariparsad   +4 more
wiley   +1 more source

Navigating the Uncertainties of Antithrombotic Therapy After Transcatheter Patent Foramen Ovale Closure: A Comprehensive Review

Catheterization and Cardiovascular Interventions, Volume 106, Issue 3, Page 2037-2047, September 1, 2025.
ABSTRACT The patent foramen ovale (PFO), present in 25% of the population, can cause paradoxical embolism and stroke. Transcatheter PFO closure is the gold standard for recurrent embolism with significant inter‐atrial shunting, with recent trials confirming its superiority in reducing ischemic stroke recurrence over medical therapy.
Eirini Beneki, Kyriakos Dimitriadis, Nikolaos Pyrpyris, Georgios Tzimas, Ioannis Skalidis, David Meier, Panagiotis Antiochos, Panagiotis Kostakis, Efthymia Pavlou, Francesco Perone, Georgios Tsivgoulis, Constantina Aggeli, Ole de Backer, Konstantinos Tsioufis   +13 more
wiley   +1 more source

Efficacy and Safety of Direct Oral Anti‐Coagulants in Painful Venous Malformations in Children

Pediatric Dermatology, Volume 42, Issue 5, Page 1020-1023, September/October 2025.
ABSTRACT Direct oral anticoagulants (DOAC), including dabigatran, apixaban, and rivaroxaban, are increasingly used in adults for painful venous malformations (VMs) instead of subcutaneous drugs such as low molecular weight heparins or fondaparinux. However, these medications are poorly studied in children. In seven children with painful VMs and chronic
Olivia Boccara, Julie Bonigen, Véronique Soupre, Eve Puzenat, Annouk Bisdorff, Ludovic Drouet   +5 more
wiley   +1 more source

Recovery of Visual Function after Administration of Dabigatran Etexilate

Case Reports in Ophthalmology, 2014
A 46-year-old Caucasian female underwent pars plana vitrectomy (ppv) for retinal detachment. After the procedure, the patient could only distinguish hand movements; the condition was tentatively diagnosed as nonarteritic anterior ischemic optic ...
Carl-Ludwig Schönfeld, Marie Fischer, Peter Distelmaier, Sebastian Philipp, Patrick Paquet, Katharina Haller, Linda Meyer   +6 more
doaj   +1 more source

Type of anaesthesia and the safety and efficacy of thromboprophylaxis with enoxaparin or dabigatran etexilate in major orthopaedic surgery: pooled analysis of three randomized controlled trials

Thrombosis Journal, 2012
Background There has been a shift towards greater use of neuraxial over general anaesthesia for patients undergoing total hip or knee arthroplasty. Furthermore, suggestions that peripheral nerve block may reduce adverse effects have recently been put ...
Rosencher Nadia, Noack Herbert, Feuring Martin, Clemens Andreas, Friedman Richard J, Eriksson Bengt I   +5 more
doaj   +1 more source

Efficacy and Safety of Anticoagulants in Patients With Cirrhosis and Portal Vein Thrombosis: A Systematic Review and Meta‐Analysis of Randomized and Non‐Randomized Studies

JGH Open, Volume 9, Issue 8, August 2025.
ABSTRACT Background Portal vein thrombosis (PVT) contributes substantially to morbidity and mortality in cirrhotic patients. A clear insight into the anticoagulation therapy benefits in these patients could improve clinical decision‐making. This meta‐analysis aimed to assess the efficacy and safety of Anticoagulants in cirrhotic patients with PVT ...
Muhammad Hassan Waseem, Zain ul Abideen, Marium Khan, Barka Sajid, Noor Ul Huda Ramzan, Rabeya Farid, Javed Iqbal, Jalib Ahmed, Aqsa Kabir, Maryam Shahzad, Javeria Asif, Muhammad Osama, Sania Aimen, Ammad Javaid Chaudhary, Ameer Haider Cheema   +14 more
wiley   +1 more source

Dabigatran etexilate and COVID-19

, 2021
Thrombotic complications are frequent in COVID-19. There is evidence supporting the use of prophylactic dose low molecular weight heparin (LMWH) as prophylaxis for venous thromboembolism in critically ill patients. Indeed, all patients with COVID-19 that are admitted to hospital should receive prophylactic dose of LMWH.
openaire   +1 more source

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

British Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 2028-2044, July 2025.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia, Brahim Achour, Zubida M. Al‐Majdoub, Amin Rostami‐Hodjegan, Jill Barber   +4 more
wiley   +1 more source

Deciphering the Relative Contribution of CYP3A4 Versus P‐Glycoprotein for the Shared Substrate Cyclosporine—Commentary on Lown et al.

Clinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1546-1561, June 2025.
The oral bioavailability of cyclosporine, a substrate of both CYP3A4 and P‐glycoprotein, is subject to large inter‐individual variability, which requires frequent monitoring of plasma concentrations. In 1997, the study by Lown et al. showed that—in addition to hepatic CYP3A4—the expression of P‐gp in the intestine significantly influences the ...
Ingolf Cascorbi, Richard B. Kim
wiley   +1 more source

Coagulopathy and Extremely Elevated PT/INR after Dabigatran Etexilate Use in a Patient with End-Stage Renal Disease

Case Reports in Medicine, 2013
Introduction. Dabigatran is an oral direct thrombin inhibitor which has been approved for prophylaxis of stroke in patients with atrial fibrillation. The use of dabigatran etexilate increased rapidly due to many benefits.
Joonseok Kim, Mrinal Yadava, In Chul An, Abrar Sayeed, Heather S. Laird-Fick, Venu Gourineni, George S. Abela   +6 more
doaj   +1 more source