Results 131 to 140 of about 389,747 (282)
A Structural Safety Analysis of Buildings During Construction [PDF]
, 1981 The safety of steel buildings, constructed by the tier method, is evaluated. The probability of failure of steel frames supported on temporary connections is examined during the different stages of completion.
Ang, A.H-S., Karshenas, S.
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Modelling the behaviour of nutrients in the coastal waters of Scotland - an update on inputs from Scottish aquaculture and their impact on eutrophication status [PDF]
, 2005 A previous study estimated that salmon farming contributed approximately 6% of Scotland's nitrogen-nutrient input to coastal waters, and 13% of phosphorus (based on 2001 production figures).
Davies, I.M. +6 more
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Sensor validation of a Structural Health Monitoring Process for Aircraft Nacelle [PDF]
, 2014 This paper details the implementation process of an embedded structural health monitoring (SHM) system enabling condition-based maintenance of aircraft nacelles.
FENDZI, Claude +4 more
core +3 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Heating and cooling a tri-level house with a hydronic baseboard-valance system [PDF]
, 1966 Cover title.Prepared as part of an investigation conducted by the Engineering Experiment Station, University of Illinois at Urbana ...
Fitch, Calvin H. +2 more
core
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Development of a renewable hybrid power plant with extended utilization of pumped storage unit equipment [PDF]
, 2019 The scheme of a renewable hybrid power plant with the extended use of the installed equipment of the pumped storage unit for the conversion of the photovoltaic and wind generators direct current to the alternating one is proposed.
Chervonenko, I. +2 more
core