ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Mobilités quotidiennes et inégalités socio-territoriales à Bogotá, Santiago du Chili et São Paulo
Espace populations sociétés, 2010 The role of daily mobility as a socio-spatial inequalities factor is a key issue in Latin America and is partly attributable to urbanisation patterns on this continent: a rather advanced urban transition, low density and wide spread millionaire ...
Florent Demoraes +4 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Espace populations sociétés, 2010 Within a context of deep poverty, how does one accomplish daily travel in Sub-Saharan African cities and which strategies for adaptation one is brought to develop?
Lourdes Diaz Olvera +3 more
doaj +1 more source
Improving activity recognition using a wearable barometric pressure sensor in mobility-impaired stroke patients. [PDF]
, 2015 © 2015 Massé et al.Background: Stroke survivors often suffer from mobility deficits. Current clinical evaluation methods, including questionnaires and motor function tests, cannot provide an objective measure of the patients mobility in daily life ...
Aminian, K +5 more
core +3 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Développement Durable et Territoires, 2018 By determining social representations of mobility, this article allows a better understanding of the actions undertaken by the stakeholders of mobility.
Julien Schiebel
doaj +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Transportation and access to urban services in Dar es Salaam [PDF]
Transportation in Dar es Salaam is particularly difficult. Statistical data drawn from the 1993 Human Resources Development Survey confirm that in unplanned settlements, transportation conditions and access to urban services are less favourable than in ...
Didier Plat +2 more
core
Parental perceived neighborhood attributes : associations with active transport and physical activity among 10-12 year old children and the mediating role of independent mobility [PDF]
, 2014 Background: During the last decades, the use of active travel modes declined in all age groups. Childhood is a critical time to establish lifelong healthy patterns. To develop effective interventions in this age group, insight in the correlates of health
Cardon, Greet +3 more
core +2 more sources