Results 91 to 100 of about 1,773,066 (262)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

ACTH vs Vigabatrin in Infantile Spasms

Pediatric Neurology Briefs, 1999
The comparative efficacy and safety of ACTH (110 IU/m2 once daily for 15 days) and vigabatrin (100-150 mg/kg/daily in bid doses) was evaluated by a retrospective analysis of medical records of 42 infants (21 in each group) with infantile spasms and ...
J Gordon Millichap
doaj   +1 more source

Estimating the Payoffs of Temperature-based Weather Derivatives [PDF]

Temperature-based weather derivatives are written on an index which is normally defined to be a nonlinear function of average daily temperatures. Recent empirical work has demonstrated the usefulness of simple time-series models of temperature for ...
A S Hurn, Adam Clements, K A Lindsay
core  

Scaling and memory of intraday volatility return intervals in stock market

, 2005
We study the return interval $\tau$ between price volatilities that are above a certain threshold $q$ for 31 intraday datasets, including the Standard & Poor's 500 index and the 30 stocks that form the Dow Jones Industrial index. For different threshold $
F. Omori, Fengzhong Wang, H. Eugene Stanley, J.-P. Bouchaud, K. Yamasaki, Kazuko Yamasaki, N. F. Johnson, R. Mantegna, Shlomo Havlin, T. Lux, Z. Ding   +10 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Evaluation of Six Neural Networks and Two Geostatistical Methods for Generating the Missing Precipitation Data [PDF]

مهندسی منابع آب, 2015
Improving the accuracy of the missing precipitation data, particularly in large watershed with low-density precipitation network, is one of the challenges of the hydrologists.
N. Tayefeh Neskili, B. Zahraei, B. S
doaj  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Daily station-level records of air temperature, snow depth, and ground temperature in the Northern Hemisphere

Scientific Data
Air temperature (Ta), snow depth (Sd), and soil temperature (Tg) are crucial variables for studying the above- and below-ground thermal conditions, especially in high latitudes.
Vinh Ngoc Tran, Wenbo Zhou, Taeho Kim, Valeriy Mazepa, Victor Valdayskikh, Valeriy Y. Ivanov   +5 more
doaj   +1 more source

Transferability across countries of equations developed using milk mid-infrared spectroscopy to estimate daily body condition score change in dairy cows

Journal of Dairy Science
: Routine milk samples are commonly subjected to spectroscopic analysis within the mid-infrared (MIR) region of the electromagnetic spectrum to estimate macro-constituents of milk such as fat, protein, lactose, and urea content.
M. Frizzarin, F. Miglior, I.C. Gormley, C. Baes, S. McParland, D.P. Berry   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source