Results 91 to 100 of about 1,771,596 (264)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Estimating the Payoffs of Temperature-based Weather Derivatives [PDF]
Temperature-based weather derivatives are written on an index which is normally defined to be a nonlinear function of average daily temperatures. Recent empirical work has demonstrated the usefulness of simple time-series models of temperature for ...
A S Hurn, Adam Clements, K A Lindsay
core
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Evaluation of Six Neural Networks and Two Geostatistical Methods for Generating the Missing Precipitation Data [PDF]
مهندسی منابع آب, 2015 Improving the accuracy of the missing precipitation data, particularly in large watershed with low-density precipitation network, is one of the challenges of the hydrologists.
N. Tayefeh Neskili, B. Zahraei, B. S
doaj
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Scientific DataAir temperature (Ta), snow depth (Sd), and soil temperature (Tg) are crucial variables for studying the above- and below-ground thermal conditions, especially in high latitudes.
Vinh Ngoc Tran +5 more
doaj +1 more source
Journal of Dairy Science: Routine milk samples are commonly subjected to spectroscopic analysis within the mid-infrared (MIR) region of the electromagnetic spectrum to estimate macro-constituents of milk such as fat, protein, lactose, and urea content.
M. Frizzarin +5 more
doaj +1 more source
Analysis of hydraulic load of a wastewater treatment plant in Jasło
Journal of Water and Land Development, 2016 The paper presents an analysis of hydraulic load in a wastewater treatment plant (WTP) in Jasło. The study was based on the records of daily sewage volume entering the treatment plant within a multi-year period of 2010–2014.
Młyński Dariusz +2 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source