Results 71 to 80 of about 1,785,229 (258)

La configuración de la identidad privada: diarios y libros de memorias en la Baja Edad Media

Historia. Instituciones. Documentos, 2002
El objetivo del presente artículo es analizar la presencia de anotaciones de carácter privado en libros de cuentas pertenecientes a mercaderes y artesanos valencianos de los años ginales de la Edad Media, y de qué modo esa presencia revela la ...
María Luz Mandingorra Llavata
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Construction and Application of Dynamic Threshold Model for Agricultural Drought Grades Based on Near-Infrared and Short-Wave Infrared Bands for Spring Maize

Remote Sensing
Maize (Zea mays L.) is one of the most important grain crops in the world. Drought caused by climate change in recent years may greatly threaten water supply and crop production, even if the drought only lasts for a few days or weeks.
Xia Wu, Peijuan Wang, Yanduo Gong, Yuanda Zhang, Qi Wang, Yang Li, Jianping Guo, Shuxin Han   +7 more
doaj   +1 more source

A validation study of the Eurostat harmonised European time use study (HETUS) diary using wearable technology

BMC Public Health, 2019
Background The central aim was to examine the accuracy of the full range of daily activities recorded in self-report time-use diaries against data from two objective passive data collection devices (wearable camera and accelerometer) serving as criterion
Teresa Harms, Jonathan Gershuny, Aiden Doherty, Emma Thomas, Karen Milton, Charlie Foster   +5 more
doaj   +1 more source

An Off-line Scan of the BATSE Daily Records and a Large Uniform Sample of Gamma-Ray Bursts

, 2001
During a scan of the archival BATSE daily records covering the entire 9.1 years (TJD 8369-11690) of the BATSE operation, 3906 gamma-ray bursts (GRBs) have been detected.
Boris E. Stern, Dmitrii Kompaneets, Juri Poutanen, Roland Svensson, Stern B. E., Yana Tikhomirova   +5 more
core   +1 more source

Reconstruction of spectral solar irradiance since 1700 from simulated magnetograms [PDF]

, 2016
We present a reconstruction of the spectral solar irradiance since 1700 using the SATIRE-T2 (Spectral And Total Irradiance REconstructions for the Telescope era version 2) model.
Dasi-Espuig, M., Jiang, J., Krivova, N. A., Solanki, S. K., Unruh, Y. C., Yeo, K. L.   +5 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

NEW DAILY TEMPERATURE RECORDS IN OLTENIA PRONOUNCED THERMAL CONTRASTS AT THE BEGINNING OF THE SUMMER 2013 [PDF]

Aerul şi Apa: Componente ale Mediului, 2014
The heat waves represent one of the consequences of the globally climate’s warming. These are usually associated with thermal discomfort and drought and sometimes are followed by intervals characterized by a high-degree atmospheric instability and/or ...
MĂNESCU CARMEN, BURADA CRISTINA, BĂCESCU ADRIANA, IORDĂCHESCU MAGDALENA   +3 more
doaj