Results 141 to 150 of about 773,400 (308)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The Effects of Daily Temperature on Crime Events in Urban Hanoi, Vietnam Using Seven Years of Data (2013-2019). [PDF]

Int J Environ Res Public Health, 2022
Le VTH, Berman JD, Tran QA, Wattenberg EV, Alexander BH.   +4 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

A daily temperature rhythm in the human brain predicts survival after brain injury. [PDF]

Brain, 2022
Rzechorzek NM, Thrippleton MJ, Chappell FM, Mair G, Ercole A, Cabeleira M, CENTER-TBI High Resolution ICU (HR ICU) Sub-Study Participants and Investigators, Rhodes J, Marshall I, O'Neill JS.   +9 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Analyzing Temperature Effects on Mortality Within the R Environment: The Constrained Segmented Distributed Lag Parameterization [PDF]

Here we present and discuss the R package modTempEff including a set of functions aimed at modelling temperature effects on mortality with time series data.
Vito M. R. Muggeo
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Energy Demand and Temperature: A Dynamic Panel Analysis [PDF]

This paper is a first attempt to investigate the effect of climate on the demand for different energy vectors from different final users. The ultimate motivation for this is to arrive to a consistent evaluation of the impact of climate change on key ...
Francesco Bosello, Giuseppe Marano, Andrea Bigano   +2 more
core  

Historical global and regional spatiotemporal patterns in daily temperature

Frontiers in Environmental Science
The abrupt increase in surface air temperature over the last few decades has received abundant scholarly and popular attention. However, less attention has focused on the specific nature of the warming spatially and seasonally, using high-resolution ...
Md Adilur Rahim, Md Adilur Rahim, Md Adilur Rahim, Robert V. Rohli, Robert V. Rohli, Rubayet Bin Mostafiz, Rubayet Bin Mostafiz, Rubayet Bin Mostafiz, Nazla Bushra, Nazla Bushra, Carol J. Friedland, Carol J. Friedland   +11 more
doaj   +1 more source

Daily Temperature Effect on Seedling Growth Dynamic of Three Invasive Alien Species. [PDF]

Front Plant Sci, 2022
Pepe M, Gratani L, Crescente MF, Puglielli G, Varone L.   +4 more
europepmc   +1 more source