Results 121 to 130 of about 773,400 (308)

Current and future climate- and air pollution-mediated impacts on human health. [PDF]

, 2009
BACKGROUND: We describe a project to quantify the burden of heat and ozone on mortality in the UK, both for the present-day and under future emission scenarios.
Massimo Vieno, Milojevic, Ai, Ruth M Doherty, Doherty, Ruth M, Ben Armstrong, Milojevic, A., Doherty, RM, Kovats, S., Stevenson, David S, Stevenson, DS, Doherty, Ruth, Wilkinson, P., Richard Atkinson, Heal, Mathew R, Pattenden, S., Heal, MR, Stevenson, David; id_orcid, Kovats, S, Paul Wilkinson, Vieno, Massimo, Armstrong, Ben, David S Stevenson, Atkinson, Richard, Atkinson, R., Atkinson, R, Chalabi, Zaid, Zaid Chalabi, Sam Pattenden, Vieno, M, Pattenden, Sam, Heal, Mathew R.; id_orcid, Mathew R Heal, Ai Milojevic, Sari Kovats, Wilkinson, Paul, Armstrong, B, Milojevic, A, Chalabi, Z., Pattenden, S, Kovats, Sari, Wilkinson, P, Chalabi, Z, Armstrong, B.   +42 more
core   +1 more source

Deep Learning for Daily 2‐m Temperature Downscaling

Earth and Space Science
This study proposes a novel method, which is a U‐shaped convolutional neural network that combines non‐local attention mechanisms, Res2net residual modules, and terrain information (UNR‐Net).
Shuyan Ding, Xiefei Zhi, Yang Lyu, Yan Ji, Weijun Guo   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Comprehensive Validation of MODIS-Derived Instantaneous Air Temperature and Daily Minimum Temperature at Nighttime

Remote Sensing
Nighttime near-surface air temperature is a critical input for ecological, hydrological, and meteorological models and the Moderate Resolution Imaging Spectroradiometer (MODIS)-derived instantaneous nighttime near-surface air temperature (Ta) and daily ...
Wenjie Zhang, Jiarui Zhao, Wenbin Zhu, Yunbo Kong, Bingcheng Wan, Yilan Liao   +5 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Forecasting from one day to one week ahead for the Spanish system operator [PDF]

This paper discusses the building process and models used by Red Eléctrica de España (REE), the Spanish system operator, in short-term electricity load forecasting.
Rosemarie Grafe, Jose Ramon Cancelo, Antoni Espasa   +2 more
core  

An ecological time-series study of heat-related mortality in three European cities. [PDF]

, 2008
BACKGROUND: Europe has experienced warmer summers in the past two decades and there is a need to describe the determinants of heat-related mortality to better inform public health activities during hot weather.
Ishigami, Ai, Luigi Bisanti, Shakoor Hajat, Antonio Russo, Ai Ishigami, Hajat, Shakoor, R Sari Kovats, Anna Paldy, Paldy, Anna, Russo, Antonio, Rognoni, Magda, Kovats, R Sari, Magda Rognoni, Bisanti, Luigi   +13 more
core   +1 more source

Modeling hourly air temperature based on internationally agreed times and the daily minimum temperature [PDF]

Revista Brasileira de Engenharia Agrícola e Ambiental
There are several fields that require knowledge of air temperature variation throughout the day, such as disease prediction or calculation of chill-hours.
Sidinei Z. Radons, Arno B. Heldwein, Luís H. Loose, Mateus P. Bortoluzzi, Silvane I. Brand, Lana B. de O. Engers   +5 more
doaj   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source