Results 101 to 110 of about 773,400 (308)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

How Predictable are Temperature-series Undergoing Noise-controlled Dynamics in the Mediterranean [PDF]

, 2011
Mediterranean is thought to be sensitive to global climate change, but its future interdecadal variability is uncertain for many climate models. A study was made of the variability of the winter temperature over the Mediterranean Sub-regional Area (MSA),
Nazzareno Diodato, Bellocchi, Gianni, Diadato, Nazzareno, Gianni Bellocchi   +3 more
core   +2 more sources

Evaluation of Daily Temperature Extremes in the ECMWF Operational Weather Forecasts and ERA5 Reanalysis

Atmosphere
In weather forecasting and climate monitoring, daily maximum and minimum air temperatures (TMAX and TMIN) are fundamental for operational and research purposes, from early warning of extreme events to climate change studies.
Francisco M. Lopes, Emanuel Dutra, Souhail Boussetta   +2 more
doaj   +1 more source

Estimates of daily global solar radiation based on the daily temperature extremes and precipitation sums

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2004
Two methods for estimating daily global solar radiation (RG) based on the daily temperature extremes and precipitation sum are compared in the study. All parameters necessary for application of both methods were derived either from literature or from ...
Miroslav Trnka
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Generation of Simulated Daily Precipitation and Air and Soil Temperatures, January 2000 [PDF]

, 2000
This paper describes a maximum likelihood method using historical weather data to estimate a parametric model of daily precipitation and maximum and minimum air temperatures.

core  

Detection of changes in temperature extremes during the second half of the 20th century [PDF]

, 2005
Since 1950, the warmest and coldest days and nights of the year have become warmer. Comparing these observations with climate model simulations in an optimal detection analysis shows a significant human influence on patterns of change in extremely warm ...
Brown, S., Christidis, N., Hegerl, G. C., Stott, P. A., Caesar, J.   +4 more
core   +1 more source

Mean January daily temperature

, 1978
The map shows the mean January daily temperature based on the 30-year period 1941-1970. The lowest mean January daily temperatures are below -35 degrees Celsius and are located on Ellesmere Island and on Axel Heiberg Island and south of the Boothia Peninsula in Nunavut.
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Modelling water temperature in TOXSWA [PDF]

, 2010
A reasonably accurate estimate of the water temperature is necessary for a good description of the degradation of plant protection products in water which is used in the surface water model TOXSWA.
Deneer, J.W., Adriaanse, P.I., Jacobs, C.M.J.   +2 more
core