Results 81 to 90 of about 773,400 (308)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Short-term effects of air pollution on a range of cardiovascular events in England and Wales: case-crossover analysis of the MINAP database, hospital admissions and mortality. [PDF]
, 2014 OBJECTIVE: To inform potential pathophysiological mechanisms of air pollution effects on cardiovascular disease (CVD), we investigated short-term associations between ambient air pollution and a range of cardiovascular events from three national ...
Smeeth, Liam +5 more
core +1 more source
علوم آب و خاک, 2019 The effects of climate change can be released from the surface to the soil depth, thereby affecting soil thermal regime. Thermal energy in the soil plays a very important role in causing climate changes. In this study, for the assessment and detection of
S. Shiukhy Soqanloo +2 more
doaj
A Simplified Method For Estimating The Peak Load In The Large Cold Stores [PDF]
Engineering and Technology Journal, 2009 In this paper a simplified method for estimating the peak load in the large coldstores is found and its occurrence day by utilizing two new variables A & B. Thefirst variable represents the number of days that is necessary for cooling theproduct (storage)
Aziz. J. Aziz +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Upper temperature limits of tropical marine ectotherms: global warming implications [PDF]
, 2011 Animal physiology, ecology and evolution are affected by temperature and it is expected that community structure will be strongly influenced by global warming.
Peck, Lloyd S. +27 more
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Nature Conservation Research: Заповедная наука, 2017 The article presents the soil temperature data obtained using two automatic weather stations located in the Mordovia State Nature Reserve (Russia). Measurements were carried out at the soil surface and at depths of 20 cm, 40 cm and 60 cm.
Oleg G. Grishutkin
doaj +1 more source
Nowcasting daily minimum air and grass temperature [PDF]
International Journal of Biometeorology, 2015 Site-specific and accurate prediction of daily minimum air and grass temperatures, made available online several hours before their occurrence, would be of significant benefit to several economic sectors and for planning human activities. Site-specific and reasonably accurate nowcasts of daily minimum temperature several hours before its occurrence ...
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source