Results 111 to 120 of about 773,400 (308)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Application of the Bias Correction and Spatial Downscaling Algorithm on the Temperature Extremes From CMIP5 Multimodel Ensembles in China

Earth and Space Science, 2019
The Bias Correction and Spatial Downscaling (BCSD) is a trend‐preserving statistical downscaling algorithm, which has been widely used to generate accurate and high‐resolution data set.
Lianlian Xu, Aihui Wang
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

McMurdo-Dry-Valleys-LTER-Meteorological-Stations-Daily-Air-Temperature [PDF]

<div> <p>Welcome to the Data Repository for <strong>Daily Air Temperatures</strong> from the McMurdo Dry Valleys Automatic Weather Stations (AWS), managed by the <strong>McMurdo Dry Valleys Long Term Ecological Research ...
McMurdo Dry Valleys Long Term Ecological Research
core   +1 more source

Improved analyses of changes and uncertainties in sea surface temperature measured in situ sice the mid-nineteenth century: The HadSST2 dataset [PDF]

, 2006
A new flexible gridded dataset of sea surface temperature (SST) since 1850 is presented and its uncertainties are quantified. This analysis [the Second Hadley Centre Sea Surface Temperature dataset (HadSST2)] is based on data contained within the ...
Folland, C. K., Kennedy, J. J., Brohan, P., Tett, S. F. B., Parker, D. E., Ansell, T. J., Rayner, N. A., Vanicek, M.   +7 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Root temperature and growth of young tomato plants [PDF]

, 1977
During recent years sophisticated techniques are applied in the glasshouse industry for the control of the glasshouse climate. Along with that development, extensive research programs were carried out to establish optimum conditions for growth.
Harssema, H.
core  

On the Applicability of Temperature and Precipitation Data from CMIP3 for China [PDF]

, 2012
Global Circulation Models (GCMs) contributed to the Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment Report (AR4) and are widely used in global change research.
Alistair G L Borthwick, Qingyun Duan, Duan Qingyun, Miao, Chiyuan, Yang Lin, Miao Chiyuan, Borthwick A. G. L., Duan, Qingyun, Yang L., Borthwick Alistair G. L., Yang, Lin, Borthwick, Alistair G. L., Duan Q. Y., Lin Yang, Miao C. Y., Chiyuan Miao, Alistair G. L. Borthwick   +16 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source