Results 181 to 190 of about 6,643,331 (384)

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response.

Molecules and Cells, 2017
Andrew N. Blackford, S. Jackson
semanticscholar   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Real-world damage accrual in Sjögren's disease: a 5-year multicentre GIRRCS cohort analysis. [PDF]

RMD Open
Berardicurti O, Marino A, Navarini L, Pilato A, Vomero M, Di Corcia LP, Genovali I, Currado D, La Barbera L, Irace R, Conigliaro P, Pavlych V, Guardo V, Carlino G, Ferrigno S, Grembiale RD, Iagnocco A, Ruscitti P, Cipriani P, Chimenti MS, Ciccia F, Guggino G, Giacomelli R.   +22 more
europepmc   +1 more source

The Cost of Flooding on Housing Under Climate Change in the Philippines: Examining Projected Damage at the Local Scale

Isaac Besarra, Aaron Opdyke, Jerico E. Mendoza, Patricia Anne Delmendo, Joy Santiago, Dino John Evangelista, Alfredo Mahar Francisco Lagmay   +6 more
openalex   +1 more source

Tornado Damage and Damage Assessment of Houses

Wind Engineers, JAWE, 2008
UEMATSU, Yasushi, OKUDA, Yasuo
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

CANNOT READ--DAMAGE

CANNOT READ--DAMAGE
core   +3 more sources

Energy Transfer Mechanism of Hard-Roof Hydraulic Fracturing in Goaf-Side Working Face Based on Microseismic-Driven Damage Model. [PDF]

Sensors (Basel)
Zhang R, Gong S, Cai W, Li H, Qiu Y.
europepmc   +1 more source

Physiological Effects of Seawater Enrichment with Dissolved Iron in Corals: Oxidative Damage Parameters as Biomarkers

Letícia May Fukushima, Juliana da Silva Fonseca, Thales Jean Vidal, Kely Paula Salvi, Carlos Henrique Figueiredo Lacerda, Patrícia Macêdo Gomes, Miguel Mies, Adalto Bianchini   +7 more
openalex   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source