Results 181 to 190 of about 1,392,331 (344)

Upregulation of Mcl-1S Causes Cell-Cycle Perturbations and DNA Damage Accumulation. [PDF]

Front Cell Dev Biol, 2020
Streletskaia AY, Senichkin VV, Prikazchikova TA, Zatsepin TS, Zhivotovsky B, Kopeina GS.   +5 more
europepmc   +1 more source

DNA damage‐induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation [PDF]

, 2023
Tsukasa Oda, Nanami Gotoh, Tetsuhiro Kasamatsu, Hiroshi Handa, Takayuki Saitoh, Nobuo Sasaki   +5 more
openalex   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Evolution of Senescence by Damage Accumulation That Accelerates With Age Throughout an Organism's Lifespan. [PDF]

Ecol Evol
Bega D, Hadany L.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Transcriptional stress in aging: integrating experimental data and modeling to quantify DNA damage accumulation. [PDF]

Front Mol Biosci
van de Grint J, Raseta M, Brandt R, van Loon Y, Demmers J, Dealy S, Chang J, Hoeijmakers J, Pothof J.   +8 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Enhancement of doxorubicin efficacy by diosmetin through DNA damage accumulation and P-glycoprotein inhibition in breast cancer cells. [PDF]

Sci Rep
Michalczyk M, Humeniuk E, Kubik J, Adamczuk G, Michalczuk M, Madej-Czerwonka B, Czerwonka M, Korga-Plewko A.   +7 more
europepmc   +1 more source

Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice

, 2010
Eva Machová, Vladimı́r Rudajev, Helena Smyčková, Henna Koivisto, Heikki Tanila, Vladimı́r Doležal   +5 more
openalex   +2 more sources

Accumulation of Amyloid Beta (Aβ) Peptide on Blood Vessel Walls in the Damaged Brain after Transient Middle Cerebral Artery Occlusion [PDF]

, 2019
António A. Martins, Astrid Zayas‐Santiago, Yancy Ferrer‐Acosta, Solianne M. Martinez-Jimenez, Lidia Zueva, Amanda Díaz-García, Mikhail Inyushin   +6 more
openalex   +1 more source