Results 51 to 60 of about 698,986 (262)

Oxidative DNA damage accumulation in gastric carcinogenesis [PDF]

Gut, 1998
Background —Gastric carcinogenesis is a multifactorial, multistep process, in which chronic inflammation plays a major role. Aims —In order to ascertain whether free radical mediated oxidative DNA damage is involved in such a process ...
FARINATI, FABIO, CARDIN, ROMILDA, DEGAN P, RUGGE, MASSIMO, DI MARIO F, BONVICINI P, NACCARATO R.   +6 more
openaire   +3 more sources

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris, Priya B. Shetty, Olga A. Taylor, Elizabeth G. Atkinson, Melissa A. Richard, M. Monica Gramatges, Mark Zobeck, Sandi Pruitt, Amy Hughes, M. Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Han Chen, Bing Yu, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L. Brown, The REDIAL Consortium   +24 more
wiley   +1 more source

Phase Angle as an Early Functional Biomarker of Cancer‐Related Fatigue in Pediatric Oncology: A Prospective Longitudinal Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric cancer remains a leading cause of morbidity and mortality worldwide, particularly in low‐and middle‐income countries. Cancer treatment may impair nutritional status, alter body composition, and exacerbate cancer‐related fatigue (CRF).
Luís Carlos Lopes‐Junior, Luiz Claudio Barreto Silva Neto, Fabiano Kenji Haraguchi, Letícia Batista de Azevedo, Marcelo Brenner Nascimento Carlini, Raphael Manhães Pessanha, Mariana Rabello Laignier, Wesley Rocha Grippa, Tania Mara Lopes Bitti Bortolini, Gláucia Zouain‐Figueiredo, Regina Aparecida Garcia de Lima, Liliana Vasquez   +11 more
wiley   +1 more source

The treatment of Fatigue and Damage Accumulation in Composite Design [PDF]

Advanced Composites Letters, 1992
SUMMARY The process of design has traditionally involved a specialized treatment of damage accumulation and associated fatigue phenomena, e.g. Miners Rule. The treatment of such phenomena for the case of advanced composites tends to be complicated by the existence of a multiplicity of competing failure modes.
K KEDWARD, P BEAUMONT
openaire   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Mechanical Performance Characteristics and Numerical Analysis of Consititutive Model for Circular Steel Pipes Considering Damage Accumulation

工程科学与技术, 2023
Since the single-layer reticulated shell structure is mainly composed of circular steel tubes, the constitutive model for circular steel tube is more suitable to study the mechanical behavior of single-layer reticulated shell structures.
Sheng HE, Yitong ZHOU, Xin XIA, Hongtao YANG, Peng YU   +4 more
doaj  

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

Real-Time Loss Tools: Open-Source Software for Time- and State-Dependent Seismic Damage and Loss Calculations – Features and Application to the 2023 Türkiye-Syria Sequence

Seismica
During a seismic sequence, the action of each earthquake has the potential to damage and weaken exposed structures, causing their fragility to change, and increasing their likelihood of being further damaged by subsequent earthquakes.
Cecilia Nievas, Helen Crowley, Graeme Weatherill, Fabrice Cotton   +3 more
doaj   +1 more source

A VIBRATIONAL DAMAGE MODEL FOR PEARS BASED ON FATIGUE ACCUMULATIVE DAMAGE THEORY [PDF]

Engenharia Agrícola
Fatigue vibration is a primary cause of fruit damage during transportation. Drawing on the Palmgren–Miner fatigue accumulation damage theory and the correlation between fruit vibration damage characteristics and external vibration excitation, this paper ...
Chenxu Zhao, Yuchi Li, Xue Huang, Shujie Song   +3 more
doaj   +1 more source

A Population‐Based Study on Childhood Aplastic Anemia—Incidence, Outcomes, and Health‐Related Quality of Life

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Childhood aplastic anemia (AA) is a rare disease, and both the disease itself and its treatment cause significant morbidity. We aimed to determine the contemporary incidence of childhood AA in Finland, to compare the clinical characteristics of AA against inherited bone marrow failure syndromes (IBMFS) and refractory cytopenia of ...
Lauri‐Matti Kulmala, Riitta Niinimäki, Tytti Pokka, Anu Huurre, Liisa Järvelä, Sauli Palmu, Tuuli Pöyhönen, Pauliina Utriainen, Henri Aarnivala   +8 more
wiley   +1 more source