Results 141 to 150 of about 3,928,621 (275)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Damage Characterization during Compression in a Perlite-Aluminum Syntactic Foam. [PDF]

Materials (Basel), 2019
Kádár C, Chmelík F, Ugi D, Máthis K, Knapek M.   +4 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Classification and Parameter Selection for Damage Characterization in CFRP Composite Materials Using Acoustic Emission and Multivariate Statistics. [PDF]

Materials (Basel)
Amoateng-Mensah D, Amevorku RD, Dhar P, Minhaj TB, Sundaresan MJ.   +4 more
europepmc   +1 more source

Damage characterization of red sandstones using uniaxial compression experiments. [PDF]

RSC Adv, 2018
Zhao K, Huang Z, Yu B.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Author Correction: Mechanical properties and damage characterization of cracked granite after cyclic temperature action. [PDF]

Sci Rep
Bao X, Wang L, Cui G, Qiao J, Tian B, Huang S, Wang L.   +6 more
europepmc   +1 more source

Nano-Level Damage Characterization of Graphene/Polymer Cohesive Interface under Tensile Separation. [PDF]

Polymers (Basel), 2019
Koloor SSR, Rahimian-Koloor SM, Karimzadeh A, Hamdi M, Petrů M, Tamin MN.   +5 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Mechanical properties and damage characterization of cracked granite after cyclic temperature action. [PDF]

Sci Rep
Bao X, Wang L, Cui G, Qiao J, Tian B, Huang S, Wang L.   +6 more
europepmc   +1 more source