Results 101 to 110 of about 1,805,455 (304)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Research on Bridge Integrity Assessment and Early Warning Monitoring Methods Based on Bearing Reaction Force

Buildings
Traditional bridge monitoring and damage identification techniques typically rely on full-bridge coverage of sensors, such as displacement or strain sensors.
Shu Li, Luyi Gan, Ruinan Zhao, Shenao Wang, Yu Zhou   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Enhancing the Damage Detection and Classification of Unknown Classes with a Hybrid Supervised–Unsupervised Approach

Infrastructures
Most damage-assessment strategies for dynamic systems only distinguish between undamaged and damaged conditions without recognizing the level or type of damage or considering unseen conditions.
Lorenzo Stagi, Lorenzo Sclafani, Eleonora M. Tronci, Raimondo Betti, Silvia Milana, Antonio Culla, Nicola Roveri, Antonio Carcaterra   +7 more
doaj   +1 more source

Experimental evaluation of three leak detection and location concepts for space stations [PDF]

Three leak (or precursor damage modes) detection and location concepts for space station overboard leakage were evaluated experimentally. The techniques are: (1) static and dynamic seal leak detector sensing of moisture or all gases in space cabin ...
Kazokas, G. P., Mackallor, D. C., Mastandrea, J. R., Scherb, M. V., Zelik, J. A.   +4 more
core   +1 more source

Detecting Damage in Composites [PDF]

Mechanical Engineering, 1998
Research shows that polarimetric optical-fiber sensors embedded in composite laminates can monitor structural integrity and detect damage while the structure remains in service. An experimental arrangement can be created to monitor strain in composite specimens.
openaire   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Trend Decomposition for Temperature Compensation in a Radar-Based Structural Health Monitoring System of Wind Turbine Blades

Sensors
The compensation of temperature is critical in every structural health monitoring (SHM) system for achieving maximum damage detection performance. This paper analyses a novel approach based on seasonal trend decomposition to eliminate the temperature ...
Jonas Simon, Jochen Moll, Viktor Krozer
doaj   +1 more source

Dynamic characterisation of a damaged composite structure with stiffeners employing fibre bragg gratings [PDF]

, 2011
One of the key issues in composite structures for aircraft applications is the early detection and localisation of damage. Often service induced damage does not involve visible plastic deformation, but internal matrix related damage, like transverse ...
Akkerman, R., Boer, A. de, Grooteman, F.P., Loendersloot, R., Ooijevaar, T.H., Warnet, L.L.   +5 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source