Results 111 to 120 of about 1,232,743 (307)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Damage Spreading in the Ising Model
, 1997 We present two new results regarding damage spreading in ferromagnetic Ising models. First, we show that a damage spreading transition can occur in an Ising chain that evolves in contact with a thermal reservoir.
A. M. Mariz +24 more
core +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
EVOLUTIONAL BUILDING DAMAGE PREDICTION
Journal of Structural and Construction Engineering (Transactions of AIJ), 2009 We hypothesized that the scale of the predicted Nankai Earthquake will increase gradually year by year as the time passes from the last occurrence in December 1946, and then we estimated strong motions chronologically from 2009 to 2060 for western Japan based on the up-to-date strong motion prediction method, i.e., the so-called statistical Green's ...
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Applied SciencesThe damage evolution process of layered rock is influenced by its fine structure, lamination direction, and confining pressure, exhibiting significant anisotropic characteristics. This study focuses on shale as the research object, employing indoor tests
Jiawei Liu, Shuchen Xuan, Gao Liu
doaj +1 more source
Fighter aircraft flight control technology design requirements [PDF]
, 1984 The evolution of fighter aircraft flight control technology is briefly surveyed. Systems engineering, battle damage considerations for adaptive flutter suppression, in-flight simulation, and artificial intelligence are briefly ...
Nelson, W. E., Jr.
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
, 2010 We are developing a model of vacuum arcs. This model assumes that arcs develop as a result of mechanical failure of the surface due to Coulomb explosions, followed by ionization of fragments by field emission and the development of a small, dense plasma ...
Huang, D. +5 more
core +1 more source