Results 161 to 170 of about 4,651,346 (275)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

SDFormer: A Novel Transformer Neural Network for Structural Damage Identification by Segmenting the Strain Field Map. [PDF]

Sensors (Basel), 2022
Li Z, Xu P, Xing J, Yang C.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Drive-By Bridge Damage Identification Using Successive Variational Modal Decomposition and Vehicle Acceleration Response. [PDF]

Sensors (Basel)
Jiang X, Ma K, Wu J, Li Z.
europepmc   +1 more source

Sensitivity Analysis Using a Reduced Finite Element Model for Structural Damage Identification. [PDF]

Materials (Basel), 2021
Yang Q, Peng X.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Concrete Damage Identification and Localization for Structural Health Monitoring Based on Piezoelectric Sensors. [PDF]

Sensors (Basel)
Li H, Di B, Zheng Y, Ma H, Huang X, Wu H, Zhang J.   +6 more
europepmc   +1 more source

An Unsupervised Tunnel Damage Identification Method Based on Convolutional Variational Auto-Encoder and Wavelet Packet Analysis. [PDF]

Sensors (Basel), 2022
Zhang Y, Xie X, Li H, Zhou B.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Damage Identification of Fiber-Reinforced Composite Thin Plate by Curvature Modal Shape Scanning Method. [PDF]

Materials (Basel)
Chang Y, Zhao Q, Han H, Zhao X, Qin L, Li X, Wu L, Li H.   +7 more
europepmc   +1 more source