Results 181 to 190 of about 740,837 (265)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

From Pixels to Predictions: Integrating Machine Learning and Digital Image Correlation for Damage Identification in Engineering Materials. [PDF]

Materials (Basel)
Sadeghian M, Palevicius A, Sablinskas J, Griskevicius P.   +3 more
europepmc   +1 more source

Exploration of Damage Identification Method for a Large-Span Timber Lattice Shell Structure in Taiyuan Botanical Garden based on Structural Health Monitoring. [PDF]

Sensors (Basel), 2023
Wang G, Xu C, Zhang S, Zhou Z, Zhang L, Qiu B, Wan J, Lei H.   +7 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spectral feature extraction and ensemble learning for multiclass aircraft damage identification. [PDF]

MethodsX
Zade N, Gupte A, Gupta P, Detalle N, Mannion A, Voyle R.   +5 more
europepmc   +1 more source

Solution to the problem of bridge structure damage identification by a response surface method and an imperialist competitive algorithm. [PDF]

Sci Rep, 2022
Ye D, Xu Z, Liu Y.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Research on damage identification in T-beam bridges based on strain influence lines. [PDF]

Sci Rep
Deng N, Xue W, Han Z, Hao T, Hu X, Ou J.
europepmc   +1 more source

Damage Identification of Semi-Rigid Joints in Frame Structures Based on Additional Virtual Mass Method. [PDF]

Sensors (Basel), 2022
An X, Zhang Q, Li C, Hou J, Shi Y.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source