Results 111 to 120 of about 5,763,068 (274)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Lichen Planus Activity and Damage Index (LiPADI)-Creation of the Questionnaire. [PDF]
J Clin Med, 2021 Stępień K +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 1985 This is the 1985 edition of the Index. The Index is written by student editors, and it is the college’s yearbook. It includes an annual record of events at Wooster. This specific Index is divided into different sections including college life, activities,
Editors, Index, Index Editors,
core
A domain damage index to prioritizing the pathogenicity of missense variants. [PDF]
Hum Mutat, 2021 Chen HC, Wang J, Wang J, Liu Q, Shyr Y.
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Association between SLICC/ACR damage index and outcomes for lupus patients after cardiac valve surgery. [PDF]
Interact Cardiovasc Thorac Surg, 2022 Hu SY +7 more
europepmc +1 more source
Body shape index: an index for early target organ damage in hypertension
American Journal of Translational ResearchTo investigate the relationship between obesity-related indices and target organ damage in hypertension, with the goal of improving damage prevention and treatment strategies.This retrospective study included 150 hypertension cases from January 2022 to December 2023 treated at Beijing Ditan Hospital, including 72 cases of isolated hypertension, 48 with
Wangjiang, Wei, Ping, Ding
openaire +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source