Results 141 to 150 of about 5,763,068 (274)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Assessing joint damage in juvenile idiopathic arthritis: Guide for prescribing physical exercise with the juvenile arthritis damage index. [PDF]

World J Clin Pediatr
Dos Santos WR.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Juvenile arthritis damage index predicts poor response to biological treatment: A prospective cohort study. [PDF]

World J Clin Pediatr
Kolkhidova ZA, Nikishina IP, Glukhova SI, Melikhov OG, Kostik MM.   +4 more
europepmc   +1 more source

Association of African-American ethnicity and smoking status with total and individual damage index in systemic lupus erythematosus. [PDF]

Clin Rheumatol, 2020
Kallas R, Li J, Petri M.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

The SLICC/ACR damage index, assessed using a community-based electronic healthcare record, predicts mortality in SLE patients: results from the United Kingdom Clinical Practice Research Datalink. [PDF]

Rheumatol Adv Pract
Ellis J, McHugh N, Pauling JD, Bruce IN, Gor S, Humphreys JH, Vaughan-Williams H, Korendowych E, MacFadyen C, Skeoch S, McGrogan A.   +10 more
europepmc   +1 more source

Serum interleukin-16 significantly correlates with the Vasculitis Damage Index in antineutrophil cytoplasmic antibody-associated vasculitis. [PDF]

Arthritis Res Ther, 2020
Yoon T, Pyo JY, Ahn SS, Song JJ, Park YB, Lee SW.   +5 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

A finite element reliability analysis platform for damage index-based fragility assessment of RC bridges. [PDF]

Sci Rep
Song H, Kim M, Lee YJ, Kim TH, Lee S.
europepmc   +1 more source