Results 161 to 170 of about 3,060,641 (229)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Hydrological disasters and health losses: an index-based analysis for Brazil. [PDF]

Rev Saude Publica
Pereira GP, Sousa Filho JF, Ferreira TR, Costa PVMD, Ferreira AJF, Pescarini JM, Guimarães JMN, Velasco SRM, Neves DJD, Reis JSD, Silva KCMD, Santos GFD, Silva RCR, Andrade RFS, Barreto ML.   +14 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Investigation of damage evolution in asphalt concrete under coupled ultraviolet aging and freeze-thaw cycles. [PDF]

Sci Rep
Yu Z, Cao Y, Xu X, Sun L, Ma Z, Yang J, Bo W, Dong Q, Liu Z.   +8 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Vision-Based Structural Health Monitoring of Catenary Components in UAV Inspections via Mask-Guided Asymmetrical Flow. [PDF]

Biomimetics (Basel)
Wang Q, Lan H, Zhou T, Ma N, Yang H, Yan J.   +5 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Early diagnosis of radiation-induced renal injury: from lagging indicators to multimodal, pre-fibrotic detection. [PDF]

Front Cell Dev Biol
Zhang Y, Cohen EP, Murphy SV, Zaho T, Liu H, Himburg H, Feloney MP, Schaaf GW, Atala A, Cline JM.   +9 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Assessment of muscle damage in patients with advanced Duchenne muscular dystrophy based on serum creatinine and the height-to-creatinine ratio. [PDF]

Front Neurol
Wan B, Li H, Shao J, Gao T, Shi Y, Sha C, Yu X.   +6 more
europepmc   +1 more source