Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Coherence-Based Damage Indicators for Story Stiffness Reduction from Seismic Building Responses
BuildingsCoherence-based damage indicators enable story-level assessment of reinforced concrete buildings from response measurements alone. Four indicators, the mutual information (MI), the transmissibility modal assurance criterion (TMAC), the accumulated ...
Claudia Marin-Artieda, Jale Tezcan
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Fatigue indicators for metal structures: from aircraft to bridges
AviationThe papers focus on a fatigue monitoring method for two types of engineering structures: (a) aircraft and (b) steel bridges. However, the potential application of this new approach extends beyond these examples.
Mykhailo Karuskevych +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Need for Environmental Indicators Coverage. The Ecological Footprint
EIRP Proceedings, 2016 Our paper's aim is to review some of the most relevant indicators describing the environmental damage and to affirm the need of better understanding and evaluating it.
Florian Nuta
doaj
Juvenile dermatomyositis: association between nail fold capillary end row loop- area under the curve- and disease damage indicators. [PDF]
Pediatr Rheumatol Online J, 2023 Khojah A +3 more
europepmc +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Impact of multi-heavy metal exposure on renal damage indicators in Korea: An analysis using Bayesian Kernel Machine Regression. [PDF]
Medicine (Baltimore), 2023 Choi SH, Choi KH, Won JU, Kim H.
europepmc +1 more source