Results 131 to 140 of about 3,676,094 (356)

Interacting damage models mapped onto Ising and percolation models

, 2004
We introduce a class of damage models on regular lattices with isotropic interactions, as e.g. quasistatic fiber bundles. The system starts intact with a surface-energy threshold required to break any cell sampled from an uncorrelated quenched-disorder ...
A. A. Griffith, C. E. Shannon, C. J. Thompson, D. Stauffer, F. T. Peirce, H. E. Daniels, J. O. H. Bakke, K. Huang, L. D. Landau, Renaud Toussaint, Steven R. Pride   +10 more
core   +4 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Residual Strength Analysis of a Composite Stiffened Panel After a Stiffener Debonding Using an Industrial Numerical Damage Model

Fatigue of Aircraft Structures
The increasing demand for greener aviation technology has driven the adoption of advanced composite materials in aircraft structures, offering significant weight saving and fuel efficiency improvements.
Morlet Benoît, Congourdeau Fabrice, Sola Guy, Martini Dominique, Robin Alban, Jacques Vincent   +5 more
doaj   +1 more source

Study of Damage Mechanism and Evolution Model of Concrete under Freeze–Thaw Cycles

Applied Sciences
Researching the mechanical characteristics of concrete subjected to the freeze–thaw cycle is crucial for building engineering in cold climates. As a result, uniaxial compression tests were performed on concrete samples exposed to various freeze–thaw (F–T)
Ning Zhao, Shuailong Lian
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Analysis of damage and fracture formulations in cold extrusion [PDF]

, 2017
In forming processes, components generally undergo large deformations. This induces the evolution of damage, which can influence material and product properties.
Clausmeyer, Till, Schowtjak, Alexander, Tekkaya, A. Erman   +2 more
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

A damage-plasticity model for the dynamic failure of concrete

, 2011
A constitutive model based on the combination of damage mechanics and plasticity is developed to analyse concrete structures subjected to dynamic loading. The aim is to obtain a model, which requires input parameters with clear physical meanings.
Grassl, Peter, Gylltoft, Kent, Nystrom, Ulrika, Rempling, Rasmus   +3 more
core  

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Thermodynamics of pharmacological action for electron-accepting compounds on activated or damaged cell in the context of Ling's model of the living cell [PDF]

, 2011
Vladimir Matveev, D. V. Prokhorenko
openalex   +1 more source