Results 111 to 120 of about 43,457,732 (328)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Modelling aeronautical composite laminates behaviour under impact using a saturation damage and delamination continuous material model [PDF]

open access: yes, 2010
We show that the behavior of T700/M21s and T800/M21s composite panels are affected by the influence of strain rates together with local shear and crush punch or global flexural strengths of the structure.
Salaün, Michel   +9 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Prediction of material damage in orthotropic metals for virtual structural testing [PDF]

open access: yes, 2010
Models based on the Continuum Damage Mechanics principle are increasingly used for predicting the initiation and growth of damage in materials. The growing reliance on 3-D finite element (FE) virtual structural testing demands implementation and ...
Ravindran, S.
core   +3 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

A Three-Dimensional Seismic Damage Assessment Method for RC Structures Based on Multi-Mode Damage Model

open access: yesBuildings
To rationally evaluate the seismic damage of RC structures comprehensively and multi-dimensionally, a damage index calculation method is proposed.
Xiang Guo   +4 more
doaj   +1 more source

The Creep-Damage Model of Salt Rock Based on Fractional Derivative

open access: yesEnergies, 2018
The use of salt rock for underground radioactive waste disposal facilities requires a comprehensive analysis of the creep-damage process in salt rock. A computer-controlled creep setup was employed to carry out a creep test of salt rock that lasted as ...
Hongwei Zhou   +4 more
semanticscholar   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Selective weed control using laser techniques

open access: yesJulius-Kühn-Archiv, 2012
This contribution discusses technical and growth relevant aspects of using laser techniques for weed control. The research on thermal weed control via laser first focused on the interaction of laser beams and weed plants.
Marx, Christian   +5 more
doaj   +1 more source

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