Results 91 to 100 of about 43,457,732 (328)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
New methodology for calculating damage variables evolution in Plastic Damage Model for RC structures
, 2017 The behavior of reinforced concrete (RC) structures under severe demands, as strong ground motions, is highly complex; this is mainly due to joint operation of concrete and steel, with several coupled failure modes.
B. Alfarah, F. López-Almansa, S. Oller
semanticscholar +1 more source
Damage Model and Numerical Experiment of High-Voltage Electro Pulse Boring in Granite
Energies, 2019 High-voltage electro pulse boring (EPB) has the advantages of high rock-breaking efficiency and good wall quality, and is a new and efficient potential method of rock breaking.
Chang-Ping Li +4 more
semanticscholar +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Damage mechanical properties of sandstone under combined action of freeze-thaw and load
Meitan kexue jishuEngineering rock mass in cold regions is subjected to the combined action of freeze-thaw and load for a long time, which causes deterioration in the mechanical properties of the rock mass.
Yongjun SONG, Jinghui CAO
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
An isotropic damage model for geomaterials in the Kratos framework [PDF]
, 2015 Progressive fracture in quasi-brittle materials such as concrete, rocks, soils, is often treated as strain softening in continuum damage mechanics.
Pouplana Sardà, Ignasi de +1 more
core +1 more source