Results 81 to 90 of about 3,667,481 (308)

Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan, Lydie Da Costa, Ludivine David Nguyen, Heloise Chosseler, Audrey Riquet, Benedicte Bruno, Melissa Barbati   +6 more
wiley   +1 more source

Predicting the Width of Corrosion-Induced Cracks in Reinforced Concrete Using a Damage Model Based on Fracture Mechanics

Applied Sciences, 2020
Using a finite-element scheme based on a damage model, a numerical system is developed to predict cracks in reinforced concrete beams due to corrosion expansion. The numerical results show that the width of such cracks is affected considerably by (i) the
Shinichiro Okazaki, Chisato Okuma, Mao Kurumatani, Hidenori Yoshida, Manabu Matsushima   +4 more
doaj   +1 more source

Research on Rock Damage Evolution Based on Fractal Theory-Improved Dynamic Tensile-Compression Damage Model

Energies, 2022
According to the characteristics that the dynamic tension of rock material is elastic brittle and the dynamic compression is elastic plastic, based on previous studies, the influence of initial damage is considered in the established compression damage ...
Hengyu Su, Ziyi Wang, Shu Ma
doaj   +1 more source

A damage model based on failure threshold weakening

, 2010
A variety of studies have modeled the physics of material deformation and damage as examples of generalized phase transitions, involving either critical phenomena or spinodal nucleation.
Bak, Ben-Zion, Brown, Burridge, Carlson, Clar, Coniglio, Curtin, Daniels, Dieterich, Donald L. Turcotte, Drossel, Egolf, Ferguson, Gabaix, Garcimartin, Goldenfeld, Grassberger, Hamiel, Herz, Houle, James R. Holliday, John B. Rundle, Joseph D. Gran, Katz, Klein, Klein, Kun, Lyakhovsky, Lyakhovsky, Maes, Main, Malamud, Meinders, Nechad, Newman, Newman, Phoenix, Pierce, Pradhan, Pride, Rundle, Rundle, Rundle, Rundle, Rundle, Serino, Stauffer, Thirumalai, Thirumalai, Tiampo, Turcotte, Virgilii, William Klein, Xia, Zapperi   +55 more
core   +1 more source

Gradient Damage Models for Heterogeneous Materials

SIAM Journal on Mathematical Analysis, 2023
In this paper we study the asymptotic behaviour of phase-field functionals of Am brosio and Tortorelli type allowing for small-scale oscillations both in the volume and in the diffuse surface term. The functionals under examination can be interpreted as an instance of a static gradient damage model for heterogeneous materials.
Annika Bach, Teresa Esposito, Roberta Marziani, Caterina Ida Zeppieri   +3 more
openaire   +3 more sources

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source

USING GRAPHIC MODELING TO DETERMINE THE ANGLE BETWEEN THE ROLL AXES OFVEHICLES AT THE MOMENT OF COLLISION

Теория и практика судебной экспертизы, 2015
An algorithm is proposed for determining the angle of relative position of vehicles at the moment of collision, using a graphic modeling method that involves building a damage model.
S. Zharkikh
doaj  

Compressive stress-strain behaviour of cement mortar-composites reinforced with short sisal fibre [PDF]

Materials Research, 2013
To design building elements using sisal fibre reinforced mortar composites, the stress-strain curves of the composites both under tensile and compression load is needed.
Paulo R. L. Lima, Romildo D. Toledo Filho, João A. Melo Filho   +2 more
doaj   +1 more source

Feasibility and Preliminary Efficacy of Integrative Neuromuscular Training for Childhood Cancer Survivors: A Pilot Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of childhood acute lymphoblastic leukemia (ALL) often exhibit early deficits in muscle and movement competence, which can compromise long‐term health. Integrative neuromuscular training (INT), a multifaceted approach combining fundamental movement activities with strength exercises, may help address these deficits during ...
Anna Maria Markarian, Robert U. Newton, Dennis R. Taaffe, Nicholas G. Gottardo, Santosh Valvi, Carolyn J. Peddle‐McIntyre, Jodie Cochrane Wilkie, Daniel A. Galvão   +7 more
wiley   +1 more source