Study on Statistical Damage Theory Model of Tailings in a Metal Ore under the Action of Moisture Absorption and Dehumidification Circulation [PDF]
, 2020 Bing Cao +4 more
openalex +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
A Semi-Empirical Damage Model of Helankou Rocks Based on Acoustic Emission. [PDF]
Materials (Basel), 2023 Yang Y +8 more
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Damage Model of Steel Fiber-Reinforced Coal Gangue Concrete under Freeze-Thaw Cycles Based on Weibull Distribution. [PDF]
Materials (Basel), 2023 Cheng Y +6 more
europepmc +1 more source
Size Effects on Concrete Damaged Plasticity Model [PDF]
, 2020 Mojtaba Labibzadeh
openalex +1 more source
Investigation on the ductile fracture of a high-strength dual-phase steel with anisotropic damage mechanics model [PDF]
, 2021 Zinan Li +4 more
openalex +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Damage Strength Model of Soil–Structure Interface Based on Equivalent Damage
工程科学与技术Objective Pile-soil interaction plays a critical role in slope support engineering. Since the contact surface represents the weakest link in the system, analyzing the influence of the soil shear area on the mechanical properties and the constitutive ...
Huaixin LI +5 more
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