Results 171 to 180 of about 43,457,732 (328)

AAV-NRF2 protects retinal and choroidal vasculature in a GDF15-dependent manner in an oxidative damage model of AMD. [PDF]

Proc Natl Acad Sci U S A
Wang S, Zhao S, Daniels A, Naaman E, Gardner A, Smith LEH, Cepko CL.   +6 more
europepmc   +1 more source

Damage Model of Steel Fiber-Reinforced Coal Gangue Concrete under Freeze-Thaw Cycles Based on Weibull Distribution. [PDF]

Materials (Basel), 2023
Cheng Y, Sun L, Li Y, Liu M, He R, Jin X, Jin H.   +6 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Platinum Nanozymes Counteract Photoreceptor Degeneration and Retina Inflammation in a Light-Damage Model of Age-Related Macular Degeneration. [PDF]

ACS Nano, 2023
Cupini S, Di Marco S, Boselli L, Cavalli A, Tarricone G, Mastronardi V, Castagnola V, Colombo E, Pompa PP, Benfenati F.   +9 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Progressive Damage Model for Composite Laminates in Hygrothermal Environments. [PDF]

ACS Omega
Zhou D, Liu H, Lv S, Shen B, Tong X.
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Creep damage model of deep granite under coupled temperature-stress conditions. [PDF]

Sci Rep
Hu J, Shi J, Wu J, Zhang S, Zhao Y, Zhao S, Sun Z, Dang H, Yuan H.   +8 more
europepmc   +1 more source

Study on the Damage Model of Non-Persistent Jointed Rock Mass under the Coupling of Freeze-Thaw and Shear. [PDF]

Materials (Basel), 2023
Lei D, Hu H, Chen Y, Lin H, Zhang C, Wang G, Lu Z, Zhang Y.   +7 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source