Results 191 to 200 of about 43,457,732 (328)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Orthotropic reconstruction and characterization of bone tissues through a visco-plasto-damage model. [PDF]

PLoS One
Marangon G, Fincato R, Carniel EL, Toniolo I, Berardo A, Mazzucco G.   +5 more
europepmc   +1 more source

Protective role of muscones on astrocytes under a mechanical-chemical damage model. [PDF]

Ann Transl Med, 2022
Li RF, Gui F, Yu C, Luo YM, Guo L.
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Multiscale Compressive Failure Analysis of Wrinkled Laminates Based on Multiaxial Damage Model. [PDF]

Materials (Basel)
Shi J, Yang G, Sun N, Zheng J, Qian J, Wang W, Song K.   +6 more
europepmc   +1 more source

A Damage Model of Concrete including Hysteretic Effect under Cyclic Loading. [PDF]

Materials (Basel), 2022
Liu Z, Zhang L, Zhao L, Wu Z, Guo B.
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Fatigue damage assessment of bogie frame based on an improved nonlinear cumulative damage model. [PDF]

Sci Rep
Xiao Q, Zhang M, Chang C, Gao X.
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Structural Evaluation of Steel/CFRP Hybrid Part Using Progressive Damage Model and Cohesive Zone Model. [PDF]

Materials (Basel)
Ryu JC, Kim MG, Seo JY, Lee CJ, Shin DH, Ko DC.   +5 more
europepmc   +1 more source