Results 161 to 170 of about 43,457,732 (328)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Unsteady Creep Damage Model of Rock Considering Acid Solution Corrosion. [PDF]

ACS Omega
Lv H.
europepmc   +1 more source

Constitutive Damage Model of Foamed Lightweight Concrete Using Statistical Damage Theory. [PDF]

Materials (Basel), 2023
Zhou Z, Zheng Y, Xie G, Li F, Ji Z, Gong C.   +5 more
europepmc   +1 more source

Subloading-Damage Model

The Proceedings of Conference of Kyushu Branch, 2021
K. Hashiguchi
semanticscholar   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Competitive Meso-Damage Model Dependent on Stress State for Advanced High-Strength Steels. [PDF]

Materials (Basel)
Zhu H, Li D, Liu J, Ding J, Xu W.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Research on improved nonlinear viscoelastic-plastic damage model of rock and parameter identification. [PDF]

Sci Rep
Tian X, Jia B, Sun D, Cheng Z, Tao T, Pan M.   +5 more
europepmc   +1 more source

A Semi-Empirical Damage Model of Helankou Rocks Based on Acoustic Emission. [PDF]

Materials (Basel), 2023
Yang Y, Lin Q, Ma H, Israr J, Liu W, Zhao Y, Ma W, Zhang G, Li H.   +8 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source