Results 71 to 80 of about 351,149 (262)

INFERENCE FOR THE EXTENT PARAMETER OF DAMAGE BY TSUNAMI WITH POINCARE CONES

Journal of the Japanese Society of Computational Statistics, 2018
Summary: The cone-convex hull by complement (ccc-hull) is a generalized convex hull created from Poincaré cones. We propose a new approach with the ccc-hull for the simulation of the extent of damage by a tsunami and simulate the damaged area at the time of the great East Japan earthquake for approximate damage by samples from a twodimensional non ...
Nagai, Toshimasa, Kamakura, Toshinari
openaire   +3 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Damage detection in beams by using artificial neural networks and dynamical parameters

Revista Facultad de Ingeniería Universidad de Antioquia, 2012
In this paper is presented a multilayer perceptron neural network combined with the Nelder-Mead Simplex method to detect damage in multiple support beams. The input parameters are based on natural frequencies and modal flexibility.
Jesús D. Villalva, Ivan D. Gomez, José E. Laier   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Damage detection using parameter dependent dynamic experiments and wavelet transformation

Journal of Civil Engineering and Management, 2004
The paper deals with a class of problems, where localised damage is detected using static and dynamic tests. Response of a structure is analysed employing discrete wavelet transformation as a tool for signal processing.
Andrzej Garstecki, Anna Knitter‐Piatkowska, Zbigniew Pozorski, Krzysztof Ziopaja   +3 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Effects of Perforating Parameters on Casing Damage

Shiyou jixie, 2023
During oilfield development,casing deformation has become a critical factor affecting wellbore integrity and oilfield long life cycle.In order to solve the problem of perforated casing damage,a nonlinear yield analysis was conducted on perforated casing ...
Mu Zongjie, Ma Bojiaer, Xu Maoya, Wang Zhenquan   +3 more
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

A novel model for low-cycle multiaxial fatigue life prediction based on the critical plane-damage parameter. [PDF]

Sci Prog, 2020
Liu J, Lv X, Wei Y, Pan X, Jin Y, Wang Y.   +5 more
europepmc   +1 more source