Results 251 to 260 of about 875,259 (309)
Advanced Healthcare Materials, EarlyView.Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales +12 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Magnetic Ion Channel Activation (MICA) enables remote stimulation of mechanosensitive ion channels using functionalised magnetic nanoparticles, enhancing extracellular vesicle (EV) biogenesis is pre‐osteoblasts. MICA desrived EVs exhibit typical nano‐vesicular characteristics but display superior pro‐osteogeneic activity, promoting mesenchymal stem ...
Afeesh Rajan Unnithan +9 more
wiley +1 more source
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Current Opinion in Cell Biology, 2016
Accurate chromosomal DNA replication is fundamental for optimal cellular function and genome integrity. Replication perturbations activate DNA damage tolerance pathways, which are crucial to complete genome duplication as well as to prevent formation of deleterious double strand breaks.
Dana, Branzei, Ivan, Psakhye
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Accurate chromosomal DNA replication is fundamental for optimal cellular function and genome integrity. Replication perturbations activate DNA damage tolerance pathways, which are crucial to complete genome duplication as well as to prevent formation of deleterious double strand breaks.
Dana, Branzei, Ivan, Psakhye
openaire +2 more sources
Damage Tolerance of Composite Cylinders
SAE Technical Paper Series, 1983<div class="htmlview paragraph">The fracture of pressurized graphite/epoxy cylinders was investigated and their damage tolerance assessed. The cylinders were 610 mm (24 in) long and 305 mm (12 in) in diameter and were fabricated from Hercules A370-5H/3501-6 prepreg cloth in 4-ply configurations: (0,45)<sub>s</sub> and (45,0)<sub>
Michael J. Graves, Paul A. Lagace
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2001
Abstract This article addresses the issue of the implementation of composite damage tolerance requirements as it relates to military aircraft. It presents a brief introduction on the durability impact threat, damage tolerance impact threat, and other damage tolerance damage threats.
Mike R. Woodward, Rich Stover
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Abstract This article addresses the issue of the implementation of composite damage tolerance requirements as it relates to military aircraft. It presents a brief introduction on the durability impact threat, damage tolerance impact threat, and other damage tolerance damage threats.
Mike R. Woodward, Rich Stover
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International Journal of Fatigue, 1994
This paper is dedicated to my friend and colleague Professor Dr Jaap Schijve, required to retire like many good aircraft components according to a «safe life» criterion but who is still young in mind, body and spirit, has not yet reached his unfactored endurance limit, and who could continue subject to a needed change in philosophy to «retirement for ...
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This paper is dedicated to my friend and colleague Professor Dr Jaap Schijve, required to retire like many good aircraft components according to a «safe life» criterion but who is still young in mind, body and spirit, has not yet reached his unfactored endurance limit, and who could continue subject to a needed change in philosophy to «retirement for ...
openaire +1 more source
Modelling of Continuing Damage for Damage Tolerance Analysis
2011This paper presents and compares two continuing damage modelling approaches: a simplified approach, which approximately models diametrical cracks as two independent radial cracks, and an improved approach that accurately models the interaction between the cracks.
Bombardier, Yan +2 more
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Damage tolerant design demonstration
25th Structures, Structural Dynamics and Materials Conference, 1984This paper presents static failure strengths at various environments and room temperatureldry fatigue thresholds of delaminated and impact damaged graphitelepoxy coupons and stringer-stiffened wing skin panels. Damage due to external low velocity impact, in terms of either static failure strength or normalized fatigue threshold, is found to be more ...
J. HOPPER, G. MILIZIANO, E. DEMUTS
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Damage-tolerance strategies for nacre tablets
Journal of Structural Biology, 2016Nacre, a natural armor, exhibits prominent penetration resistance against predatory attacks. Unraveling its hierarchical toughening mechanisms and damage-tolerance design strategies may provide significant inspiration for the pursuit of high-performance artificial armors.
Shengnan, Wang +4 more
openaire +2 more sources
2001
The spirit of Glare is its crack bridging mechanism, which provides superior damage tolerance properties. Depending on the specific property, Glare shows either monolithic metal or composite behaviour. This challenges the definition of strength justification and certification procedures.
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The spirit of Glare is its crack bridging mechanism, which provides superior damage tolerance properties. Depending on the specific property, Glare shows either monolithic metal or composite behaviour. This challenges the definition of strength justification and certification procedures.
openaire +1 more source