Results 81 to 90 of about 355,992 (315)
EngIn nature, organisms have evolved unique structures that feature low weight, high strength, and damage resistance. The Eurasian eagle-owl serves as a representative example, with specialized feather architectures that enable stable flight in intense and ...
Jing Yan, Yi Li
doaj +1 more source
Energy-absorbing wood composite for improved damage tolerance inspired by mollusc shells
Materials Research Express, 2020 The crossed lamellar structure (CLS) found in mollusc shells is an excellent example for nature’s ability to form complex hierarchical microstructures with a remarkable balance between strength and toughness.
Maximilian Pramreiter +6 more
doaj +1 more source
, 2007 Bypassing of DNA lesions by damage-tolerant DNA polymerases depends on the interaction of these enzymes with the monoubiquitylated form of the replicative clamp protein, PCNA.
Bielen, Aleksandra B. +3 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
MetalsThis article comprehensively reviews the fatigue crack growth (FCG) models applied to Ti6Al4V alloy manufactured by electron beam melting (EBM) powder bed fusion (PBF).
Nicole Atmadja, Mamidala Ramulu
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Fatigue of Aircraft Structures, 2015 Knowledge about loads occurring in the structure during aircraft operation is vital from the point of view of the damage tolerance approach to aircraft design. In the best-life scenario, such information could be available from a network of sensors, e.g.
Dziendzikowski Michał +6 more
doaj +1 more source
About the impact behavior of woven-ply carbon fiber-reinforced thermoplastic- and thermosetting-composites: A comparative study [PDF]
, 2013 This study is aimed at comparing the response of TS-based (epoxy) and TP-based (PPS or PEEK) laminates subjected to low velocity impacts. C-scan inspections showed that impact led to diamond-shaped damage resulting from different failure mechanisms ...
Vieille, Benoit +5 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source