Results 91 to 100 of about 389,715 (294)
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
International Competition Law: antitrust Damages Directive
, 2017 This article builds on previous works examining whether private enforcement should be prioritised over public enforcement for breaches of competition law within the EC.
Flaherty, Ruth
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Statement supporting European Directive 2010/63/EU (“Directive”) on the protection of animals used for scientific purposes [PDF]
, 2014 The use of animals in research has facilitated major breakthroughs in medicine which have transformed human and animal health. We support research using animals where alternative methods are not available, where the potential benefits to health are ...
DIRECTIVE
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
AI assessment tools for decision-making on telemedicine: liability in case of mistakes
Discover Artificial IntelligenceThe implementation of artificial intelligence as a medical decision support tool for triage, such as the SmED system in Germany, raises its potential application as a medical decision support for the use of telemedicine.
Sandra Camacho Clavijo
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Towards the EU Directive in respect of the breaches of competition [PDF]
Zbornik Radova Pravnog Fakulteta u Splitu, 2015 In the proceedings conducted by the competition authorities (ili ako ste mislili baš na našu agenciju, onda the Croatian Competition Agency umjesto „the competition authorities“), the injured third parties are not entitled to claim for compensation of ...
Jelena Čuveljak
doaj +2 more sources
A repository of recovered materials from post-earthquake reconstruction areas
Techne, 2018 Following the series of ‘severe’ seismic events that began in 2009, Italian legislation classified demolition debris as urban waste, despite Directive 2008\98\EC calling for the reuse/recycling of 70% of all waste from human activities by 2020.
Filippo Angelucci +3 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source