Results 161 to 170 of about 389,715 (294)

Novel product, familiar challenges: Navigating uncertainty in oral nicotine pouch regulation. [PDF]

Addiction
Tonti L, Pesko MF.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Embedding national procedural autonomy in the Directive on Damages’

, 2016
peer reviewedThis chapter outlines to what extent the EU damages Directive deviates from or takes into account the requirements of equivalence and effectiveness underlying the principle of national procedural autonomy in EU law.
Van Cleynenbreugel, Pieter
core  

Gender-Based Cyberviolence Prevention in European Secondary Education: A Scoping Review on the Intersection Between Comprehensive Sexuality Education and Digital Literacy. [PDF]

J Sch Health
Piras V, Chakraborty A.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Back to the Future: Reintroduction into the Wild of the Italian Grey Partridge (<i>Perdix perdix italica</i> Hartert, 1917). [PDF]

Animals (Basel)
Riga F, Gabbrielli C, Greco C, Montanaro P, Mucci N, Senserini D, Tabarroni C, Tramontana D, Volani S.   +8 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Catching up with drought: law and policy responses in the Netherlands. [PDF]

Reg Environ Change
Augustijn MFW, Alblas E, Richter A.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Que peut-on attendre de la directive services ? [PDF]

L’article s’intéresse aux effets prévisibles de la Directive Services. En premier lieu il étudie les trois manières d’interpréter l’expression commerce de services : celle des Comptes nationaux, celle de la Balance des Transactions Courantes et celle de ...
Damien Broussolle
core