Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li +11 more
wiley +1 more source
Simultaneous multi-controller fusion via genetic algorithm-optimized weighted summation for variable-speed wind turbine control. [PDF]
Chahbi A +5 more
europepmc +1 more source
A Smart Fluid‐Hydraulic System Based on MRF Valve Control and Its Application in Flexible Grasping
This study introduces a smart fluid hydraulic system using MRF valve control for flexible gripping. An MRF‐MSV with an integrated excitation coil and micro‐textured damping channels is designed and validated; micro‐texturing increases hydraulic resistance. Coupled with a soft actuator, the MRF‐MSV enables dynamic bending and grasping.
Linfeng Huo +5 more
wiley +1 more source
Dynamic mode decomposition for analysis and prediction of metabolic oscillations from time-lapse imaging of cellular autofluorescence. [PDF]
Wüstner D, Gundestrup HH, Thaysen K.
europepmc +1 more source
A novel multiscale MD/DFT framework to elucidate microenzyme adsorption and electron transfer is reported. This method reveals distinct configurations for microperoxidase‐11 on graphene and those best suited for electron transfer. Rate constants align with the limited experimental data, establishing this framework as a tool for optimizing microenzyme ...
Milan Mijajlovic +6 more
wiley +1 more source
Nonlinear magnetic ring model based on impedance measurements with DC-bias current. [PDF]
Kutorasiński K +3 more
europepmc +1 more source
Combining template stripping with a graphene‐inspired transfer yields continuous, transferable gold films at 6‐inch wafer scale with thicknesses approaching the atomic limit. The atomically smooth, near‐bulk‐quality films offer above 86% transmittance and sub‐20 Ω/square sheet resistance, serving as a universal platform for flexible optoelectronics ...
Dmitry Yakubovsky +24 more
wiley +1 more source
Geographic Disparities in Access to Glaucoma Surgery: Lessons from a Nationwide Registry Study. [PDF]
Samuelsen JN +5 more
europepmc +1 more source
Real‐Time Investigation of Interfacial Evolution in Electrochemical Energy Storage Systems via EQCM
Understanding the electrode/electrolyte interface (EEI) is crucial for supercapacitors and batteries. EQCM, by enabling real‐time monitoring of mass changes during charge–discharge cycles, has evolved into a vital method for analysis of EEI. It provides important insights into charge‐storage mechanisms, electrode structural evolution, ion‐transfer ...
Zixuan Wang, Situo Cheng, Guang Feng
wiley +1 more source
Design and Application of Fluorescence Probes for Gold Nanocage Complex Perovskite Quantum Dots. [PDF]
Liu Y +5 more
europepmc +1 more source

