Results 221 to 230 of about 102,554 (312)

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Dynamic Repellency of Water-Proof Surfaces. [PDF]

ACS Nano
Zhan Z, Yu C, Liu Z, Li C, Jiang L, Dong Z.   +5 more
europepmc   +1 more source

Interfacial Engineering by Metallic Ions and Organic Ammonium Ligand Passivation for Perovskite Solar Cells

Advanced Science, EarlyView.
A synergistic approach using phenethylammonium iodide (PEAI) and antimony iodide (SbI3) enhances the operational stabilities of perovskite solar cells by providing p‐type doping effect, suitable band energy alignment, reduced defect density, and minimized surface ion vacancies in the perovskite films.
Abraham Adenle, Purevlkham Myagmarsereejid, Selengesuren Suragtkhuu, Tuul Tsagaantsooj, Solongo Purevdorj, Eric Campbell, Sina Jamali, Oisín E. FitzGerald, Taylor J. Z. Stock, Thomas J. Macdonald, Joseph F. S. Fernando, Hui Jin, Paul E. Shaw, Michitoshi Hayashi, Batjargal Sainbileg, Chihaya Adachi, Yu Lin Zhong, Munkhbayar Batmunkh   +17 more
wiley   +1 more source

Coupled oscillator mechanism extends the amplifying effect of outer hair cells to high frequencies. [PDF]

Sci Rep
Iwasa KH.
europepmc   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Design and Testing of an Emg-Controlled Semi-Active Knee Prosthesis. [PDF]

Sensors (Basel)
Ozhikenov K, Nurgizat Y, Ayazbay AA, Uzbekbayev A, Sultan A, Nussibaliyeva A, Zhetenbayev N, Kalykpaeva R, Sergazin G.   +8 more
europepmc   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Revisiting the impulse response creates an improved PID autotuner. [PDF]

Sci Rep
Keyser R, Birs IR, Muresan CI, Ionescu CM.   +3 more
europepmc   +1 more source

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

Advanced Science, EarlyView.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren, Zhihong Deng, Sheng Lu, Jing Zhang, Wenbin Liu, Jia Tan   +5 more
wiley   +1 more source